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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Mini-Review Article

Role of Unani Polyherbal Formulations in the Treatment of Diseases with Special Reference to Neurodegenerative Disorders

Author(s): Yasir Hasan Siddique*

Volume 22, Issue 3, 2023

Published on: 06 April, 2022

Page: [321 - 328] Pages: 8

DOI: 10.2174/1871527321666220127141611

open access plus

Abstract

Unani system of medicine is based on the use of natural plant products. Unani polyherbal formulations (UPFs) are being prescribed for the treatment of various ailments. The preparations of the UPFs also required the animal products such as honey and umber. UPFs have been reported to cure various diseases but still lack scientific credibility. The Unani system is based on the holistic approach; the synergistic role of the compounds has been suggested to play a protective role against the illness. The present review has compiled the studies carried out on UPFs used to treat various diseases with special reference to neurodegenerative ailments. The exorbitant cost of conventional treatment has led the world to think towards alternative therapy with less cost and no or little side effects compared to conventional treatments. More research is required for UPFs on the experimental models along with the case controlled studies in order to establish UPFs in the mainstream of treatment.

Keywords: Unani medicine, neurodegenerative disorders, polyherbal formulations, validation, efficacy, safety.

[1]
Hussain A, Sofi GD, Tajuddin T, Dang R, Kumar N. Unani system of medicine-introduction and challenges. Med J Islamic World Acad Sci 2010; 18: 27-30.
[2]
Lone AH, Ahmad T, Anwar M, Sofi G, Imam H, Habib S. Perception of health promotion in Unani herbal medicine. J Herb Med 2012; 2: 1-5.
[http://dx.doi.org/10.1016/j.hermed.2012.02.003]
[3]
Ahmad B, Akhtar J. Unani system of medicine. Pharmacogn Rev 2007; 1: 210.
[4]
Ansari S, Khan QA, Anjum R, Siddiqui A, Sultana K. Fundamentals of Unani system of medicine-A review. Euro J Biomed Pharm Sci 2017; 4: 219-23.
[5]
Bilen J, Bonini NM. Drosophila as a model for human neurodegenerative disease. Annu Rev Genet 2005; 39: 153-71.
[http://dx.doi.org/10.1146/annurev.genet.39.110304.095804] [PMID: 16285856]
[6]
Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 2009; 7(1): 65-74.
[http://dx.doi.org/10.2174/157015909787602823] [PMID: 19721819]
[7]
Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 2004; 3(3): 205-14.
[http://dx.doi.org/10.1038/nrd1330] [PMID: 15031734]
[8]
Ambikar DB, Birru EM, Patil MJ. Influence of Unani polyherbal formulation on learning and memory retention in mice. Pharm Sci Asia 2018; 45: 174-83.
[http://dx.doi.org/10.29090/psa.2018.03.174]
[9]
Zhu M, Han S, Fink AL. Oxidized quercetin inhibits α-synuclein fibrillization. Biochim Biophys Acta 2013; 1830(4): 2872-81.
[http://dx.doi.org/10.1016/j.bbagen.2012.12.027] [PMID: 23295967]
[10]
Papandreou MA, Kanakis CD, Polissiou MG, et al. Inhibitory activity on amyloid-β aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J Agric Food Chem 2006; 54(23): 8762-8.
[http://dx.doi.org/10.1021/jf061932a] [PMID: 17090119]
[11]
Baptista FI, Henriques AG, Silva AM, Wiltfang J, da Cruz e Silva OA. Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer’s disease. ACS Chem Neurosci 2014; 5(2): 83-92.
[http://dx.doi.org/10.1021/cn400213r] [PMID: 24328060]
[12]
Srivastava P, Yadav RS. Efficacy of natural compounds in neurodegenerative disorders. In: Essa M, Akbar M, Guillemin G, Eds. The Benefits of Natural Products for Neurodegenerative Diseases. Cham: Springer 2006; pp. 107-23.
[13]
Saki K, Bahmani M, Rafieian-Kopaei M, Hassanzadazar H, Dehghan K, Bahmani F. The most common native medicinal plants used for psychiatric and neurological disorders in Urmia city, northwest of Iran. Asian Pac J Trop Dis 2014; 4: S895-901.
[http://dx.doi.org/10.1016/S2222-1808(14)60754-4]
[14]
Akram M, Nawaz A. Effects of medicinal plants on Alzheimer’s disease and memory deficits. Neural Regen Res 2017; 12(4): 660-70.
[http://dx.doi.org/10.4103/1673-5374.205108] [PMID: 28553349]
[15]
Ali SK, Hamed AR, Soltan MM, et al. In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of Alzheimer disease. BMC Complement Altern Med 2013; 13: 121.
[http://dx.doi.org/10.1186/1472-6882-13-121] [PMID: 23721591]
[16]
AlMatar M, Islam MR, Albarri O, Var I, Koksal F. Pomegranate as a possible treatment in reducing risk of developing wound healing, obesity, neurodegenerative disorders, and diabetes mellitus. Mini Rev Med Chem 2018; 18(6): 507-26.
[http://dx.doi.org/10.2174/1389557517666170419114722] [PMID: 28425868]
[17]
Shamsi Y, Nikhat S, Mukherjee A, Gombar V, Sinha S. Role of Unani neuroprotective herbal drugs in the management of autism. Internat J Res Rev 2019; 6: 12-20.
[18]
Boehm K, Raak C, Vollmar HC, Ostermann T. An overview of 45 published database resources for complementary and alternative medicine. Health Info Libr J 2010; 27(2): 93-105.
[http://dx.doi.org/10.1111/j.1471-1842.2010.00888.x] [PMID: 20565550]
[19]
Sehar N, Khan MA, Salam MU. The drugs used in the management of duf’al dimagh (cerebro asthenia) in Unani system of medicine. Faslnamah-i Giyahan-i Daruyi 2019; 7: 29-33.
[20]
Bhat MD, Malik R. Pharmacological profile and uses of sumbul-ut-teeb (Nardostachys jatamansi) in Unani system of medicine. Internat J Adv Compl Trad Med 2017; 3: 51-8.
[21]
Siddique YH, Mujtaba SF, Faisal M, Jyoti S, Naz F. The effect of Bacopa monnieri leaf extract on dietary supplementation in transgenic Drosophila model of Parkinson’s disease. Eur J Integr Med 2014; 6: 571-80.
[http://dx.doi.org/10.1016/j.eujim.2014.05.007]
[22]
Salim S, Ahmad M, Zafar KS, Ahmad AS, Islam F. Protective effect of Nardostachys jatamansi in rat cerebral ischemia. Pharmacol Biochem Behav 2003; 74(2): 481-6.
[http://dx.doi.org/10.1016/S0091-3057(02)01030-4] [PMID: 12479970]
[23]
Singh P, Guleri R, Singh V, et al. Biotechnological interventions in Withania somnifera (L.) Dunal. Biotechnol Genet Eng Rev 2015; 31(1-2): 1-20.
[http://dx.doi.org/10.1080/02648725.2015.1020467] [PMID: 25787309]
[24]
Saroya AS, Singh J. Neuropharmacology of Celastrus paniculatus Willd. Pharmacotherapeutic potential of natural products in neurological disorders. Singapore: Springer 2018; pp. 135-9.
[http://dx.doi.org/10.1007/978-981-13-0289-3_12]
[25]
Ishrat T, Hoda MN, Khan MB, et al. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of Sporadic Dementia of Alzheimer’s Type (SDAT). Eur Neuropsychopharmacol 2009; 19(9): 636-47.
[http://dx.doi.org/10.1016/j.euroneuro.2009.02.002] [PMID: 19329286]
[26]
Gangopadhyay A, Sinha S, Chaulya NC, Ghosh A. Phytochemical investigation and exploration of CNS depressant efficacy of ethanolic root extract of Cyperus kyllinga Endl. Indian J Experiment Biol 2017; 55(11): 801-4.
[27]
Singh B, Pandey S, Verma R, Singh S, Mahdi AA. Neuroprotective role of Mucuna pruriens in Parkinson_ampersandsignrsquo; S disease model system. Ijrdpl 2016; 5: 2397-404.
[28]
Subash S, Essa MM, Al-Asmi A, et al. Pomegranate from Oman alleviates the brain oxidative damage in transgenic mouse model of Alzheimer’s disease. J Tradit Complement Med 2014; 4(4): 232-8.
[http://dx.doi.org/10.4103/2225-4110.139107] [PMID: 25379464]
[29]
Khan MB, Hoda MN, Ishrat T, et al. Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment. Neurol Sci 2012; 33(5): 1011-20.
[http://dx.doi.org/10.1007/s10072-011-0880-1] [PMID: 22170092]
[30]
Dar NJ, Hamid A, Ahmad M. Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cell Mol Life Sci 2015; 72(23): 4445-60.
[http://dx.doi.org/10.1007/s00018-015-2012-1] [PMID: 26306935]
[31]
Feyzabadi Z, Ghorbani F, Vazani Y, Zarshenas MM. A critical review on phytochemistry, pharmacology of Viola odorata L. and related multipotential products in traditional Persian medicine. Phytother Res 2017; 31(11): 1669-75.
[http://dx.doi.org/10.1002/ptr.5909] [PMID: 28948657]
[32]
Singh D, Singh B, Goel RK. Traditional uses, phytochemistry and pharmacology of Ficus religiosa: A review. J Ethnopharmacol 2011; 134(3): 565-83.
[http://dx.doi.org/10.1016/j.jep.2011.01.046] [PMID: 21296646]
[33]
Sajjad N, Wani A, Sharma A, et al. Artemisia amygdalina upregulates Nrf2 and protects neurons against oxidative stress in Alzheimer disease. Cell Mol Neurobiol 2019; 39(3): 387-99.
[http://dx.doi.org/10.1007/s10571-019-00656-w] [PMID: 30725250]
[34]
Ansari N, Khodagholi F. Natural products as promising drug candidates for the treatment of Alzheimer’s disease: Molecular mechanism aspect. Curr Neuropharmacol 2013; 11(4): 414-29.
[http://dx.doi.org/10.2174/1570159X11311040005] [PMID: 24381531]
[35]
Dong J, Cui Y, Li S, Le W. Current pharmaceutical treatments and alternative therapies of Parkinson’s disease. Curr Neuropharmacol 2016; 14(4): 339-55.
[http://dx.doi.org/10.2174/1570159X14666151120123025] [PMID: 26585523]
[36]
Figueira I, Menezes R, Macedo D, Costa I, Dos Santos CN. Polyphenols beyond barriers: A glimpse into the brain. Curr Neuropharmacol 2017; 15(4): 562-94.
[http://dx.doi.org/10.2174/1570159X14666161026151545] [PMID: 27784225]
[37]
da Costa IM, Freire MAM, de Paiva Cavalcanti JRL, et al. Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer’s disease: A systematic review. Curr Neuropharmacol 2019; 17(5): 406-21.
[http://dx.doi.org/10.2174/0929867325666180117112610] [PMID: 29338678]
[38]
Rehman MU, Wali AF, Ahmad A, et al. Neuroprotective strategies for neurological disorders by natural products: An update. Curr Neuropharmacol 2019; 17(3): 247-67.
[http://dx.doi.org/10.2174/1570159X16666180911124605] [PMID: 30207234]
[39]
Murray AP, Faraoni MB, Castro MJ, Alza NP, Cavallaro V. Natural AChE inhibitors from plants and their contribution to Alzheimer’s disease therapy. Curr Neuropharmacol 2013; 11(4): 388-413.
[http://dx.doi.org/10.2174/1570159X11311040004] [PMID: 24381530]
[40]
Fan D, Liu L, Wu Z, Cao M. Combating neurodegenerative diseases with the plant alkaloid berberine: Molecular mechanisms and therapeutic potential. Curr Neuropharmacol 2019; 17(6): 563-79.
[http://dx.doi.org/10.2174/1570159X16666180419141613] [PMID: 29676231]
[41]
Dias KS, Viegas C Jr. Multi-target directed drugs: A modern approach for design of new drugs for the treatment of Alzheimer’s disease. Curr Neuropharmacol 2014; 12(3): 239-55.
[http://dx.doi.org/10.2174/1570159X1203140511153200] [PMID: 24851088]
[42]
Lee WH, Loo CY, Bebawy M, Luk F, Mason RS, Rohanizadeh R. Curcumin and its derivatives: Their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol 2013; 11(4): 338-78.
[http://dx.doi.org/10.2174/1570159X11311040002] [PMID: 24381528]
[43]
Aliev G. Pharmacological approaches targeting brain cell survival in the context of neurodegeneration and potential treatment strategies. Curr Neuropharmacol 2019; 17(3): 198-200.
[http://dx.doi.org/10.2174/1570159X17666181227163039] [PMID: 30592253]
[44]
Hatziagapiou K, Kakouri E, Lambrou GI, Bethanis K, Tarantilis PA. Antioxidant properties of Crocus sativus L. and its constituents and relevance to neurodegenerative diseases; Focus on Alzheimer’s and Parkinson’s disease. Curr Neuropharmacol 2019; 17(4): 377-402.
[http://dx.doi.org/10.2174/1570159X16666180321095705] [PMID: 29564976]
[45]
Carrera I, Cacabelos R. Current drugs and potential future neuroprotective compounds for parkinson’s disease. Curr Neuropharmacol 2019; 17(3): 295-306.
[http://dx.doi.org/10.2174/1570159X17666181127125704] [PMID: 30479218]
[46]
Giulietti A, Vignini A, Nanetti L, Mazzanti L, Di Primio R, Salvolini E. Alzheimer’s disease risk and progression: The role of nutritional supplements and their effect on drug therapy outcome. Curr Neuropharmacol 2016; 14(2): 177-90.
[http://dx.doi.org/10.2174/1570159X13666150928155321] [PMID: 26415975]
[47]
Liu L, Liu C, Wang Y, Wang P, Li Y, Li B. Herbal medicine for anxiety, depression and insomnia. Curr Neuropharmacol 2015; 13(4): 481-93.
[http://dx.doi.org/10.2174/1570159X1304150831122734] [PMID: 26412068]
[48]
Siddique YH, Naz F, Rahul, Rashid M, Tajuddin. Effect of Majun Baladur on life span, climbing ability, oxidative stress and dopaminergic neurons in the transgenic Drosophila model of Parkinson’s disease. Heliyon 2019; 5(4): e01483.
[http://dx.doi.org/10.1016/j.heliyon.2019.e01483] [PMID: 31011645]
[49]
Khan MB, Hoda MN, Yousuf S, et al. Prevention of cognitive impairments and neurodegeneration by Khamira Abresham Hakim Arshad Wala. J Ethnopharmacol 2006; 108(1): 68-73.
[http://dx.doi.org/10.1016/j.jep.2006.04.012] [PMID: 16765546]
[50]
Siddique YH, Naz F, Rashid M. Effect of polyherbal drug Majun falasfa on the transgenic Drosophila model of Parkinson’s disease. Curr Trad Med 2021; 7(5): e281220189535.
[51]
Syeda A, Rughooputh S, Greenwell P. The Unani system of medicine: Does it have a scientific basis? Biomed Sci 2004; 48: 971-2.
[52]
Yousuf S, Atif F, Hoda N, et al. Oral supplementation of Majun Baladar ameliorates antioxidant enzyme activities in cerebral ischaemic damage. Basic Clin Pharmacol Toxicol 2007; 101(4): 246-53.
[http://dx.doi.org/10.1111/j.1742-7843.2007.00110.x] [PMID: 17845506]
[53]
Afrin Z, Siddiqui A, Jafri MA, Vohora D, Asif M. Evaluation of anticonvulsant activity of Majoon Najah in experimental animal model. Asian J Pharm Pharmacol 2019; 5: 660-8.
[http://dx.doi.org/10.31024/ajpp.2019.5.4.2]
[54]
Ahmed M, Azmat A. Decreased brain serotonin turnover rate following administration of Sharbat-e-Ahmed Shah produces antidepressant and anxiolytic effect in rats. Metab Brain Dis 2017; 32(6): 1785-90.
[http://dx.doi.org/10.1007/s11011-017-0065-6] [PMID: 28687902]
[55]
Rabbani SA, Ali SM. Pharmacological studies on khamira marwarid: Effect on pentylenetetrazole-induced seizures, cognition and biochemical markers in mice. Iranian J Pharmacol Therap 2014; 12: 71-80.
[56]
Khan ZA, Ansari AN, Zia MA. Efficacy of munzij wa Mus’ hil-e-Balgham and Zimad-e-Sheetraj on motor recovery in Falij-e-Nisfi (hemiplegia). Internat J Unani Integra Med 2019; 3: 45-50.
[57]
Singh S, Nair V, Gupta YK. Antiarthritic activity of majoon suranjan (a polyherbal Unani formulation) in rat. Indian J Med Res 2011; 134: 384-8.
[PMID: 21985823]
[58]
Afzal M, Khan NA, Ghufran A, Iqbal A, Inamuddin M. Diuretic and nephroprotective effect of Jawarish Zarooni Sada--a polyherbal Unani formulation. J Ethnopharmacol 2004; 91(2-3): 219-23.
[http://dx.doi.org/10.1016/j.jep.2003.12.029] [PMID: 15120442]
[59]
Abdul L, Abdul R, Sukul RR, Nazish S. Anti-inflammatory and antihistaminic study of a unani eye drop formulation. Ophthalmol Eye Dis 2010; 2: 17-22.
[http://dx.doi.org/10.4137/OED.S3612] [PMID: 23861612]
[60]
Lone AH, Habib S, Ahmad T, Anwar M. Effect of a polyherbal Unani formulation in acne vulgaris: A preliminary study. J Ayurveda Integr Med 2012; 3(4): 180-3.
[http://dx.doi.org/10.4103/0975-9476.104430] [PMID: 23326087]
[61]
Singh S, Kumar R, Jain H, Gupta YK. Anti-inflammatory and antiarthritic activity of UNIM-301 (a polyherbal Unani formulation) in Wistar rats. Pharmacognosy Res 2015; 7(2): 188-92.
[http://dx.doi.org/10.4103/0974-8490.150515] [PMID: 25829793]
[62]
Subramaneyaan M, Yasmeen S, Arora VK, Tripathi AK, Banerjee BD, Ahmed RS. Safety evaluation and therapeutic efficacy of Habb-e-Asgand, a commonly used antirheumatic polyherbal Unani formulation. Altern Ther Health Med 2013; 19(5): 52-9.
[PMID: 23981406]
[63]
Shamsi Y, Kumar H, Tamanna SA, Khan EA. Effect of a polyherbal Unani formulation on chronic urticaria. Indian J Tradit Knowl 2006; 5: 279-83.
[64]
Ikram M, Rather GJ, Zaigham M. Quality standard of safoof razyanaj: A Unani polyherbal powder formulation. J Young Pharm 2019; 11: 361-5.
[http://dx.doi.org/10.5530/jyp.2019.11.74]
[65]
Ali M, Ansari AN, Nayab M, Anjum H, Ansari S. Efficacy of a poly-herbal Unani formulation and dry cupping in treatment of post-stroke hemiplegia: An exploratory, single arm clinical traditional. Adv Integr Med 2021; 8(4): 298-304.
[http://dx.doi.org/10.1016/j.aimed.2020.11.001]
[66]
Ali SM, Alam M, Jamal A. Clinical evaluation of the efficacy of polyherbal Unani formulations in scabies. Indian J Tradit Knowl 2006; 5: 220-3.
[67]
Ahmed D, Sharma M, Mukerjee A, Ramteke PW, Kumar V. Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation “Qurs Tabasheer” in streptozotocin induced diabetic rats. BMC Complement Altern Med 2013; 13: 10.
[http://dx.doi.org/10.1186/1472-6882-13-10] [PMID: 23305114]
[68]
Ganga B, Wadud A, Jahan N, Makbul SAA. Anti-inflammatory and analgesic activity of Habbe Gule Aakh, A polyherbal Unani formulation in animal models. J Ayurveda Integr Med 2018; 13: 1-16.
[PMID: 30414716]
[69]
Mohsin M, Khan AB, Hakim MH, Latafat T. Therapeutic evaluation of Qalbeen-A polyherbal mineral formulation in ischaemic heart disease. Indian J Tradit Knowl 2008; 7: 575-80.
[70]
Ahmed D, Sharma M, Mukerjee A, Kant RK, Kumar V. Antidiabetic, Anti-hyperlipidemic & Hepatoprotective effect of a Polyherbal Unani formulation “Qurs Tabasheer” in STZ-diabetic Wistar rats. Nat Preced 2012; 1-19.
[71]
Agrawal SS. Anti-inflammatory and anti-microbial activity of Zuroor-e-gaozaban: A polyherbal Unani formulation. Hamdard Medicus (Pakistan) 2006; 49: 9-12.
[72]
Azmat A, Ahmed M, Haider S, Haleem DJ, Syed NZ, Ahmad I. Neuropharmacological profile of somina (a poly herbal Unani formulation) in rats and mice. Niger J Nat Prod Med 2005; 9: 48-52.
[73]
Lone AH, Ahmad T, Anwar M, Sofi G. Clinical efficacy and safety of a pharmacopial polyherbal Unani formulation in pityriasis versicolor: A comparative randomized single-blind study. J Altern Complement Med 2012; 18(10): 978-82.
[http://dx.doi.org/10.1089/acm.2011.0520] [PMID: 22871048]
[74]
Tarannum A, Sultana A, Rahman K. Usefulness of polyherbal Unani formulations on Lequesne Algo-Functional Index of knee osteoarthritis: A pretest and posttest evaluation study. ASL-Musculoskeletal Dis 2013; 1(1): 9.
[75]
Siddiqui MSA, Saeed A, Nawaz A, Naveed S, Usmanghani K. The effects of new polyherbal Unani formulation AJMAL06 on serum creatinine level in chronic renal failure. Pak J Pharm Sci 2016; 29(2) (Suppl.): 657-61.
[PMID: 27113299]
[76]
Petchi RR, Vijaya C, Parasuraman S. Antidiabetic activity of polyherbal formulation in streptozotocin - nicotinamide induced diabetic wistar rats. J Tradit Complement Med 2014; 4(2): 108-17.
[http://dx.doi.org/10.4103/2225-4110.126174] [PMID: 24860734]
[77]
Ali M, Khan SA, Chang PS, Haque R, Bhatia K, Ahmad S. Habb-e-Asgand, polyherbal Unani formulation, protects liver and antioxidative enzymes against paracetamol induced hepatotoxicity. Pharm Biol 2014; 52: 506-15.
[http://dx.doi.org/10.3109/13880209.2013.863949] [PMID: 24392788]
[78]
Shakya AK, Shukla S. Evaluation of hepatoprotective efficacy of Majoon-e-Dabeed-ul-ward against acetaminophen-induced liver damage: A Unani herbal formulation. Drug Dev Res 2011; 72: 346-52.
[http://dx.doi.org/10.1002/ddr.20436]
[79]
Bhusan SH, Kumar AA, Ashish TF, Lal KM. Evaluation of polyherbal formulation for diuretic activity in albino rats. Asian Pac J Trop Dis 2012; 2: S442-5.
[http://dx.doi.org/10.1016/S2222-1808(12)60200-X]
[80]
Nishat A, Sultana S, Sultana A. A comparative study of polyherbal Unani formulations in gestational urinary tract infections. J Exp Integr Med 2017; 7: 1.
[http://dx.doi.org/10.5455/jeim.290117.or.166]
[81]
Subramaneyaan M, Yasmeen S, Ahmed RS, Arora VK, Tripathi AK, Banerjee BD. Evaluation of therapeutic efficacy of Majoon Suranjan, a Unani formulation, in the treatment of rheumatoid arthritis: An experimental study. Exp Biol Med (Maywood) 2013; 238(12): 1379-87.
[http://dx.doi.org/10.1177/1535370213498983] [PMID: 24006307]
[82]
Siddiqui AUH, Alvi R, Khan Z. Efficacy of polyherbal formulation with regimenal therapy in knee osteoarthritis at Shamim Ahmad Saeedi Unani Speciality Hospital for waja-ul-mufasil (joint pain), funded by the ministry of Ayush. Res Rev J Ayur Sci Yoga Naturo 2019; 6: 1-4.
[83]
Tabassum K, Banu KS. Effect of herbal (Unani) poly formulation on oligomenorrhoea (Qilat E Tams)- A clinical study. J Res Educ Indian Med 2008; 14: 53-6.
[84]
Ganesan R, Doss HM, Rasool M. Majoon ushba, a polyherbal compound ameliorates rheumatoid arthritis via regulating inflammatory and bone remodeling markers in rats. Cytokine 2016; 77: 115-26.
[http://dx.doi.org/10.1016/j.cyto.2015.11.002] [PMID: 26556105]
[85]
Goyal S, Siddiqui MK, Siddiqui KM, et al. Cardioprotective effect of ‘Khamira Abresham Hakim Arshad Wala’ a Unani formulation in isoproterenol-induced myocardial necrosis in rats. Exp Toxicol Pathol 2010; 62(1): 61-74.
[http://dx.doi.org/10.1016/j.etp.2009.02.115] [PMID: 19285846]
[86]
Urooj M, Husain GM, Nadeem M, Naikodi MAR, Alam M, Kazmi MH. Antiepileptic and antidepressant activity of majoon najah (a traditional Unani formulation) in experimental animals. Intern J Pharma Inves 2020; 10: 396-401.
[http://dx.doi.org/10.5530/ijpi.2020.3.70]
[87]
Nafees M, Khan NA, Amin KMY, Ahmad G. Antinociceptive and antipyretic effect in animal models treated with a polyherbal unani medicine-Habb-E-Gul-E-Aakh. Pharma Sci Monitor 2014; 5: 163-72.
[88]
Nimmi OS, George P. Antiobesity and antioxidant effects of a new polyherbal formulation (PHF) in obesity induced Wistar rats. Indian J Tradit Knowl 2017; 16: 297-302.
[89]
Mistry S, Dutt KR, Jena J. Formulation and evaluation of hepatoprotective polyherbal formulation containing indigenous medicinal plants. Int J Pharm Tech Res 2012; 4: 1238-41.
[90]
Azmi AA, Jamali SH, Murad RA, Zaidi AH. Antibacterial activity of Joshanda: A polyherbal therapeutic agent used in common cold. Pak J Pharmacol 2010; 27: 25-8.
[91]
Khan Q. Efficacy of Unani formulations in psoriasis: A case series study at NIUM hospital. Intern J Unani Integ Med 2019; 3: 110-1.
[92]
Shakya AK, Sharma N, Saxena M, Shrivastava S, Shukla S. Evaluation of the antioxidant and hepatoprotective effect of Majoon-e-Dabeed-ul-ward against carbon tetrachloride induced liver injury. Exp Toxicol Pathol 2012; 64(7-8): 767-73.
[http://dx.doi.org/10.1016/j.etp.2011.01.014] [PMID: 21371873]
[93]
Tabasum H, Ahmad T, Anjum F, Rehman H. The effect of Unani antiacne formulation (Zimade Muhasa) on acne vulgaris: A single-blind, randomized, controlled clinical trial. J Pakistan Ass Derma 2016; 24: 319-26.
[94]
Ahmad F, Rashid H, Bhatia K, et al. Modulatory effect of a Unani formulation (Jawarish amla sada) on cyclophosphamide-induced toxicity in tumour bearing mice 2012; 2: 454-68.
[95]
Shailajan S, Joshi M, Singh D, Gurjar D, Tiwari B. Efficacy of a traditional unani formulation Jawarish-e-Amla Sada against CCl 4 induced liver toxicity in Albino Wistar rats: Comparison with silymarin treatment. Intern J Green Pharm 2015; 9: 100-3.
[http://dx.doi.org/10.4103/0973-8258.155055]
[96]
Rao US, Kausar SA, Janarthanam RB, Djearamane S, Kumar SS. Biochemical evaluation of antidiabetic effect of kasini ashshifa, a polyherbal formulation in high fat diet fed-low dose STZ induced diabetes in rats. Res J Pharma Technol 2020; 13: 1474-82.
[http://dx.doi.org/10.5958/0974-360X.2020.00269.3]
[97]
Khan MS, Ansari AN. Effect of leech therapy (Irsal-e Alaq) and unani formulation (Itrifal Sagheer with Zanjabeel) in the management of varicose veins (Dawali): An open, randomized, standard controlled, three groups clinical trial. Spatula DD 2015; 5: 41-50.
[http://dx.doi.org/10.5455/spatula.20150701034914]
[98]
Alam S, Khan NA. Carbon tetrachloride (CCl4)-induced hepatotoxicity in rats: Curative role of Dawa-ul-Qust (A Unani compound formulation). Intern J Adv Pharmacy Med Bio allied Sci 2015; 3(37): 41.
[99]
Najmi AK, Pillai KK, Pal SN, Aqil M. Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats. J Ethnopharmacol 2005; 97(3): 521-5.
[http://dx.doi.org/10.1016/j.jep.2004.12.016] [PMID: 15740890]
[100]
Ansari MM, Khan NA. Evaluation of anti-inflammatory activity of qurs-e-mafasil jadeed. Indian J Pharma Biol Res 2014; 2: 27-33.
[http://dx.doi.org/10.30750/ijpbr.2.2.6]
[101]
Siddique YH, Naz F, Rashid M, Mian S. Effect of Itrifal Muqawwi-e-Dimagh (a polyherbal drug) on the transgenic Drosophila model of Parkinson’s Disease. Phytomedicine Plus 2021; 1(4): 100131.
[http://dx.doi.org/10.1016/j.phyplu.2021.100131]
[102]
Singh A, Kalaivani M, Chaudhary P, Srivastava S, Goyal RK, Gupta SK. Opportunities and challenges in development of phytopharmaceutical drug in India-A SWOT analysis. J Young Pharm 2019; 11(3): 322-7.
[http://dx.doi.org/10.5530/jyp.2019.11.66]
[103]
Yousuf S, Salim S, Ahmad M, Ahmed AS, Ansari MA, Islam F. Protective effect of Khamira Abresham Uood Mastagiwala against free radical induced damage in focal cerebral ischemia. J Ethnopharmacol 2005; 99(2): 179-84.
[http://dx.doi.org/10.1016/j.jep.2004.12.035] [PMID: 15894124]
[104]
Yousuf S, Atif F, Ahmad M, Ishrat T, Khan B, Islam F. Neuroprotection offered by Majun Khadar, a traditional Unani medicine, during cerebral ischemic damage in rats. Evid Based Complement Alternat Med 2011; 2011: 754025.
[http://dx.doi.org/10.1093/ecam/nep224] [PMID: 20047892]
[105]
Ghazanfar K, Ahmad Dar S, Akbar S, et al. Safety evaluation of Unani formulation: Capsule Shaqeeqa in albino Wistar rats. Scientifica (Cairo) 2016; 2016: 2683403.
[http://dx.doi.org/10.1155/2016/2683403] [PMID: 27190679]
[106]
Pejin B, Kien-Thai Y, Stanimirovic B, Vuckovic G, Belic D, Sabovljevic M. Heavy metal content of a medicinal moss tea for hypertension. Nat Prod Res 2012; 26(23): 2239-42.
[http://dx.doi.org/10.1080/14786419.2011.648190] [PMID: 22236074]
[107]
Haji A, Anwar M, Ansari AN, Sofi G, Shah AH. Efficacy of massage with roghan seer in motor recovery in hemiplegia secondary to ischaemic stroke. Indian J Tradit Knowl 2011; 10: 31-5.
[108]
Dadhania VP, Trivedi PP, Vikram A, Tripathi DN. Nutraceuticals against neurodegeneration: A mechanistic insight. Curr Neuropharmacol 2016; 14(6): 627-40.
[http://dx.doi.org/10.2174/1570159X14666160104142223] [PMID: 26725888]
[109]
Sen S, Chakraborty R. Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future. J Tradit Complement Med 2016; 7(2): 234-44.
[http://dx.doi.org/10.1016/j.jtcme.2016.05.006] [PMID: 28417092]
[110]
Ifeoma O, Oluwakanyinsola S. Screening of herbal medicines for potential toxicities. In: Gowder SJT, Ed. New Insights into Toxicity and Drug Testing; London UK: InTechOpen 2013; pp. 63-88.
[http://dx.doi.org/10.5772/54493]

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