Synthesis and Synthetic Applications of α-Amino Ketones Derived from Natural α-Amino Acids

Jose   M.   Concellon; Humberto      Rodriguez-Solla

doi:10.2174/138527208784245996

Abstract

Enantiomerically pure α-amino ketones are of great importance in natural product synthesis and pharmacological research. However no review concerning their synthesis and applications has been published. Therefore, this review is intended to highlight the above compounds, detailing the available methodologies to prepare enantiopure α-amino ketones in the first part and some synthetic application in the second.

Keywords: organolithium reagents, amino ketones, Weinreb amides, chemical transformations, Reduction, Glycinamides

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Current Organic Chemistry

Title: Synthesis and Synthetic Applications of α-Amino Ketones Derived from Natural α-Amino Acids

Volume: 12 Issue: 7

Author(s): Jose M. Concellon and Humberto Rodriguez-Solla

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Keywords: organolithium reagents, amino ketones, Weinreb amides, chemical transformations, Reduction, Glycinamides

Abstract: Enantiomerically pure α-amino ketones are of great importance in natural product synthesis and pharmacological research. However no review concerning their synthesis and applications has been published. Therefore, this review is intended to highlight the above compounds, detailing the available methodologies to prepare enantiopure α-amino ketones in the first part and some synthetic application in the second.

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Concellon M. Jose and Rodriguez-Solla Humberto, Synthesis and Synthetic Applications of α-Amino Ketones Derived from Natural α-Amino Acids, Current Organic Chemistry 2008; 12 (7) . https://dx.doi.org/10.2174/138527208784245996