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Review Article

Omega-3脂肪酸联合化疗预防癌症毒性、耐药性和转移

卷 23, 期 6, 2022

发表于: 01 September, 2021

页: [574 - 596] 页: 23

弟呕挨: 10.2174/1389450122666210901121935

价格: $65

摘要

尽管在癌症治疗方面取得了进步，但被诊断为癌症的个体往往面临着转移、肿瘤复发、治疗耐药性以及传统化疗、放疗和内分泌疗法的脱靶毒性的风险。具有强大的抗癌和抗转移活性但副作用较轻的药物可以与常规治疗相结合，以增加疗效，减少治疗耐药性，并减少毒性。来自流行病学、细胞培养、动物和临床研究的大量数据已经确定无毒的omega-3脂肪酸具有抗癌潜力。本文重点介绍了omega-3脂肪酸与常规治疗联合使用对防止转移、提高疗效、防止常规治疗引起的脱靶毒性的有益作用。这些omega-3脂肪酸靶向治疗诱导的中枢作用因子NF-κB和ROS，以防止药物相关的转移、治疗耐药性和脱靶毒性。

关键词: 化疗，omega-3脂肪酸，转移，治疗耐药，毒性，NF-κB, ROS。

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