摘要
背景:有效治疗病毒感染的可用抗病毒药物的抗病毒耐药性和低效促使世界各地的许多研究人员探索药用植物及其分离的化合物作为替代抗病毒药物。马斯卡林群岛丰富的植物群也因其广泛的治疗活性(包括其抗病毒特性)而被彻底研究。 目的:本综述的目的是突出马斯卡林地方性和本土药用植物的抗病毒倾向。 方法:通过主要数据库和其他主要信息来源对文献进行审查。报道了导致50%病毒抑制的抑制浓度/有效剂量(IC50/ED50)、导致细胞活力降低50%的细胞毒浓度(CC50)和选择性指数(SI),并讨论了抗病毒作用机制。 结果: Stillingia lineata 对基孔肯雅病毒(SI:10.9)最有效,在其分离的化合物中,12-O-acetylphorbol-13(2″-methyl)-butyrate 和 12-deoxyphorbol-13(2″-methyl)丁酸盐是基孔肯雅病毒复制最有效和选择性的抑制剂(SI:分别为 41 和 >240)。 12-O-acetylphorbol-13(2″-methyl)-butyrate, 12β-O-[nona-2Z,4E,6E-trienoyl]-4α-deoxyphorbol-13-butyrate, 12-deoxyphorbol-13(2″-methyl )butyrate 和 12-deoxyphorbol-13-[8'-oxohexadeca-2E,4E,6E-trienoate 对人类免疫缺陷病毒-I (SI: 36-899) 和 II (SI: 33-2056) 具有很强的选择性抗病毒作用. Obetia ficifolia 和 Erythroxylon laurifolium 对疱疹病毒最有效(SI:分别为 18.5 和 16)。 Labourdonnaisia glauca 显示出有效的抗脊髓灰质炎病毒活性(SI:40),而 Badula insularis、Labourdonnaisia glauca 和 Myonima violacea 对鼻病毒具有活性(SI:1.3-2.5)。据报道,Aphloia theiformis、Doratoxylon apetalum、Phyllanthus phillyreifolius 和 Psiloxylon mauritianum 具有抗寨卡病毒和抗登革热病毒活性。 结论:睫毛膏植物呈现出具有前景的抗病毒特性谱,特别是针对寨卡病毒、登革热病毒、基孔肯雅病毒、脊髓灰质炎病毒、犀牛病毒、疱疹病毒和人类免疫缺陷病毒,这表明它们是潜在开发有效天然抗病毒药物的可行候选者。
关键词: 地方性,本土,药用植物,睫毛膏,岛屿,抗病毒药。
图形摘要
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