摘要
影响中枢神经系统(CNS)的疾病可能具有不同的病因,但它们具有共同的无症状进展,全球发病率以及对患者和公共卫生系统的生活质量产生重大影响。随着生物医学和制药技术的进步,新的和更现代的诊断方法和治疗方法被开发出来,重新利用了目前可用于治疗中枢神经系统疾病的药物。一种有吸引力的方法是使用替代药物递送平台,例如纳米载体,以及侵入性较小的给药途径,例如鼻脑,广泛探索用于将药物递送到CNS中。尽管有许多有希望的结果,但鼻子到脑的途径有一些生理限制,使得难以令人满意地递送药物以在中枢神经系统中发挥治疗活性。为了克服这些限制,具有粘膜粘附特性的纳米结构系统在过去几年中在制药研发中脱颖而出。在这次审查中;我们讨论了鼻脑途径限制如何影响药物向中枢神经系统的递送,并强调了粘膜粘附可以为这些纳米结构系统带来的好处。文献中的主要发现被汇集在一起并进行批判性讨论,重点是粘膜粘附如何改善临床中使用的分子的生物制药特性,以及它们的生物学性能。最后,得出了关于粘膜粘附纳米系统的强度点以及成功使用鼻子到脑的路线治疗影响CNS的疾病仍然需要注意的点的结论。
关键词: 神经退行性疾病,脑癌,脑部感染,情绪障碍,鼻子对脑,粘膜粘连,药物递送纳米系统。
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