Antimalarial Drug Discovery: From Quinine to the Most Recent
Promising Clinical Drug Candidates

doi:10.2174/0929867328666210803152419
摘要

疟疾是一种由疟原虫引起的热带威胁性疾病，2019年导致40.9万人死亡。20年来，东南亚耐药寄生虫的广泛流行加剧了死亡率和发病率的复杂化。在非洲出现的大多数病例中出现了耐青蒿素的疟原虫，这突出表明迫切需要使用新药。在这项努力中，世界卫生组织和疟疾药物风险项目共同为新疗法确定了明确的目标，并确定了目标候选概况。这种正在进行的新治疗方法的研究是基于药物化学中的必要劳动，这里总结了特别关注这些新型抗疟药物的先导优化、关键特性和作用模式。本文在介绍了从奎宁到最新上市的药物后，特别关注了临床和临床前阶段最有前途的抗疟候选药物的最新进展。
关键词: 疟疾、疟原虫、临床试验、药物开发、药物发现、药物、作用方式。
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DOI https://dx.doi.org/10.2174/0929867328666210803152419	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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