Bis-triazole-containing Compounds with Anticancer Potential: A Short Review

Title:Bis-triazole-containing Compounds with Anticancer Potential: A Short Review

Volume: 21 Issue: 18

Author(s): Meixiang Gao, Qiang Diao, Feng Gao, Xiangyang Sun*Jiaqi Xiao*

Affiliation:

• Department of Interventional Radiology, Qilu Hospital of Shandong University, Jinan, Shandong, 250021,China

• State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong, 250012,China

Keywords: 1, 2, 3-triazole, 1, 2, 4-triazole, Dimers, Hybrids, Anticancer, Structure-activity relationship, Dimerization.

Abstract: The development of novel anticancer agents with high efficiency is of great importance due to the severe anticancer scenario of the currently used drugs. Dimerization is a useful method to develop new drug candidates with a broad biological spectrum, enhanced activity and potency to overcome drug resistance. A wide variety of bis-triazole-containing compounds have been developed with improved properties compared with their parent compounds. These derivatives could inhibit tumor proliferation, invasion and metastasis, revealing their potential as putative anticancer candidates. This review covers the recent advances of bis-triazole-containing compounds as anticancer candidates, and the structure-activity relationship are also discussed to set up the direction for the design and development of bis-triazole-containing compounds with higher efficiency.

Cite this article as:

Gao Meixiang, Diao Qiang, Gao Feng, Sun Xiangyang*, Xiao Jiaqi*, Bis-triazole-containing Compounds with Anticancer Potential: A Short Review, Current Topics in Medicinal Chemistry 2021; 21 (18) . https://dx.doi.org/10.2174/1568026621666210728154728