Abstract
Aliphatic secondary and tertiary amines are widely used in the production of pharmaceuticals, agrochemicals, dyes, surfactants and rubber chemicals.
Most traditional synthetic methods are often unsuitable for large-scale production due to poor selectivity, harsh reaction conditions and the cost of starting materials.
In this context, hydroaminomethylation (HAM) is a very attractive catalytic process with high atom economy that starts from inexpensive reagents, such as alkenes.
This review aims to provide an updated overview of hydroaminomethylation as a useful tool for synthesizing aliphatic secondary and tertiary amines. Therefore, the discussion will focus on both unsaturated starting compounds and the amines obtained by this one-pot reaction.
Keywords: Amines, hydroaminomethylation, terminal olefins, internal olefins, oleochemicals, terpenes, asymmetric catalysis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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