针对糖尿病肾病中的 NLRP3 炎症小体

Title:Targeting the NLRP3 Inflammasome in Diabetic Nephropathy

Volume: 28 Issue: 42

关键词: NLRP3炎症小体，糖尿病肾病(DN)，炎症，NLRP3结构，终末期肾病(ESRD)， DN进展。

摘要: Diabetic nephropathy (DN) is one of the most common complications of diabetes and the main cause of end-stage renal disease (ESRD). The inflammatory response plays a key role in the pathological process of DN. As the most deeply studied inflammasome, NLRP3 should not be overlooked in DN. Its abnormal activation accelerates DN progression. In this review, we summarize our understanding of the structural composition and activation factors of the NLRP3 inflammasome. Moreover, the relationship between NLRP3 inflammasome activation, and the potential of the NLRP3 inflammasome as a therapeutic target for DN will also be discussed.

Cite this article as:

Targeting the NLRP3 Inflammasome in Diabetic Nephropathy, Current Medicinal Chemistry 2021; 28 (42) . https://dx.doi.org/10.2174/0929867328666210705153109