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Review Article

用于超声成像和靶向治疗的生物气泡

卷 29, 期 8, 2022

发表于: 05 July, 2021

页: [1316 - 1330] 页: 15

弟呕挨: 10.2174/0929867328666210705145642

价格: $65

摘要

超声不仅因其实时、无辐射、便携和低成本等优点而成为应用最广泛的医学影像诊断方式，而且通过产生一系列强大的生物效应，是一种很有前途的靶向药物/基因传递技术。微米级或纳米级超声试剂或递送载体的发展进一步使超声成为准确诊断和有效治疗的独特方式。在这篇综述中，我们介绍了一种独特的生物气体填充蛋白质纳米结构，称为气体囊泡，它具有一些超越传统微泡的独特特性。囊泡不仅可以作为超声造影剂，通过交叉调幅谐波成像等创新成像方法，还可以通过基因工程技术进一步调整和优化。此外，它们不仅可以作为声学基因报告器、声学生物传感器来监测细胞代谢，还可以作为空化核和药物载体用于治疗目的。我们重点介绍了超声成像和靶向治疗领域的最新发展和应用，并简要介绍了相应的机制。总之，这些生物气泡比传统的 MBs 具有一些优势，值得付出更多努力来促进它们的发展。

关键词: 超声成像、气体囊泡、声学报告基因、基因工程、空化、药物输送

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