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Review Article

GAG 多价系统与 Langerin 交互

卷 29, 期 7, 2022

发表于: 05 July, 2021

页: [1173 - 1192] 页: 20

弟呕挨: 10.2174/0929867328666210705143102

价格: $65

摘要

Langerin 是一种在朗格汉斯细胞表面表达的 C 型凝集素，在保护生物体免受病原体感染方面发挥着关键作用。为了实现这一目标，Langerin 提供了至少两个识别位点，一个依赖于 Ca2+，另一个不依赖于 Ca2+，它们能够识别多种碳水化合物配体。与其他凝集素相比，Langerin 可识别硫酸化糖胺聚糖 (GAG)，这是一种存在于细胞膜和细胞外基质中的复杂且异质的多糖家族，位于以 Langerin 三聚体形式产生但在单体形式中不存在的相间。这些寡糖的复杂性阻碍了开发明确的单分散结构来研究这些相互作用过程。然而，在过去的几十年中，已经描述了合成开发的改进，以实现模拟 GAG 的碳水化合物多价系统的制备。尽管有所有这些贡献，但很少有报道使用 GAG 多价结构来评估与 Langerin 的相互作用的例子。这些分子应该为探索这些 GAG-Langerin 相互作用铺平道路。

关键词: 碳水化合物，GAG，langerin，分子识别，多价系统，NMR

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