Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer

Title:Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer

Volume: 28 Issue: 25

Author(s): Xing Fei Tan, Qifan Chen, San Hue Hua and George Wai Yip*

Affiliation:

• Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore,Singapore

Keywords: Cancer, interferon-induced protein, tetratricopeptide repeats, IFIT, biomarker, prognostic factor.

Abstract: The Interferon-induced protein with tetratricopeptide repeats (IFIT) family is an important component of the antiviral immune response. There are currently four known IFIT family members in humans, namely IFIT1, IFIT2, IFIT3 and IFIT5. Recent discoveries have brought attention to the significant roles of IFITs in cancer. This review summarises current knowledge on the biological roles of different IFIT proteins in various types of malignant neoplasm, and highlights the potential use of these molecules as cancer biomarkers and prognostic factors.

Cite this article as:

Tan Fei Xing , Chen Qifan , Hua Hue San and Yip Wai George *, Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867328666210617105209