Abstract
The article provides an overview of modern concepts of induced sputum analysis and a description of the methodology and protocols for the collection of induced sputum in adults and children. This paper describes the cellular composition of induced sputum in healthy people and in patients with asthma in detail, analyses the significance of the sputum eosinophil count as a prognostic and diagnostic criterion and the role of other cells, such as neutrophils, macrophages, basophils. In this article, we review a number of asthma biomarkers of inflammation and remodeling of the airways in asthma, which can be determined in sputum (anaphylatoxin C3a, clusterin, periostin). In addition, we summarize recent data about asthma phenotypes and describe the possibilities of using induced sputum analysis as a diagnostic and therapeutic tool for personalized anti-inflammatory therapy for asthma.
Keywords: Asthma, bronchial mucosa, sputum, periostin, anaphylatoxin C3a, respiratory tract infections.
Graphical Abstract
Current Respiratory Medicine Reviews
Title:The Clinical Relevance of Differential Cell Counts in Induced Sputum and its Relationship with Various forms of Asthma
Volume: 17 Issue: 2
Author(s): Vasilii Chulkov*, Minina Elena, Larisa Medvedeva, Roman Testov and Alexei Shestakov
Affiliation:
- Department of Faculty Therapy, South Ural State Medical University, Chelyabinsk Oblast, 454092,Russian Federation
Keywords: Asthma, bronchial mucosa, sputum, periostin, anaphylatoxin C3a, respiratory tract infections.
Abstract: The article provides an overview of modern concepts of induced sputum analysis and a description of the methodology and protocols for the collection of induced sputum in adults and children. This paper describes the cellular composition of induced sputum in healthy people and in patients with asthma in detail, analyses the significance of the sputum eosinophil count as a prognostic and diagnostic criterion and the role of other cells, such as neutrophils, macrophages, basophils. In this article, we review a number of asthma biomarkers of inflammation and remodeling of the airways in asthma, which can be determined in sputum (anaphylatoxin C3a, clusterin, periostin). In addition, we summarize recent data about asthma phenotypes and describe the possibilities of using induced sputum analysis as a diagnostic and therapeutic tool for personalized anti-inflammatory therapy for asthma.
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Cite this article as:
Chulkov Vasilii *, Elena Minina , Medvedeva Larisa , Testov Roman and Shestakov Alexei , The Clinical Relevance of Differential Cell Counts in Induced Sputum and its Relationship with Various forms of Asthma, Current Respiratory Medicine Reviews 2021; 17 (2) . https://dx.doi.org/10.2174/1573398X17666210611091246
DOI https://dx.doi.org/10.2174/1573398X17666210611091246 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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