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Review Article

大麻素和心肌缺血：对心肌梗死的新见解，更新的机制，和意义

卷 29, 期 11, 2022

发表于: 08 June, 2021

页: [1990 - 2010] 页: 21

弟呕挨: 10.2174/0929867328666210608144818

价格: $65

摘要

大麻是被广泛贩卖和滥用最广泛的非法药物。与其他非法药物相比，人们越来越认识到它具有潜在的健康益处和相对较少的不良健康影响；然而，越来越多的证据清楚地表明，大麻与相当多的不良心血管事件有关。最近的研究将大麻使用与心肌梗死(MI)联系起来；然而，对其潜在机制知之甚少。心肌梗死是一种心血管疾病，其特征是心脏的氧供需不匹配，导致心肌缺血和随后的心肌坏死。由于大麻越来越被认为是心肌梗死的一个风险因素，因此越来越需要更好地了解其潜在的健康益处和后果。在这里，我们讨论了大麻导致心肌梗死风险增加的细胞机制。我们对大麻素的作用提供了全面和批判性的分析，包括调节脂肪细胞生物学、区域脂肪分布和动脉粥样硬化，以及与心肌梗死设置相关的血流动力学应激源的沉淀。通过批判性地解剖多种细胞类型中信号通路的调节，本文强调了大麻可能触发危及生命的心血管事件的机制。这为未来的药理学研究提供了一个框架，可以确定靶点或开发调节大麻对心血管系统和其他器官系统的影响的药物。大麻对自主神经流出物、血管平滑肌细胞、心肌、皮质醇水平和其他血流动力学变化的影响也被机械地回顾。

关键词: 大麻，心肌梗死，内源性大麻素系统，动脉粥样硬化，四氢大麻酚，心血管疾病。

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