Small Non-coding RNAs in Embryonic Pre-implantation

doi:10.2174/1566524021666210526162917
摘要

胚胎植入失败已被作为早期辅助生殖和妊娠的重要限制参数引入。胚胎-母体相互作用、子宫内膜容受性和植入检测包括胚胎活力。为了调节植入，多个分子可能是一致的；然而，它们的具体监管机制仍不清楚。 MicroRNAs (miRNAs) 因其对人类胚胎植入的重要作用而引起了广泛的关注。作为基因表达的转录调节因子的微小RNA（miRNA）由胚胎植入组成。最近的研究表明，miRNA 不仅在细胞内起作用，而且可以通过多种包装形式由细胞分泌到细胞外环境中，促进细胞间通讯并提供与各种条件相关的指示信息。细胞外 miRNA 的检测为植入研究提供了新的信息。对于胚胎与母体的交流，miRNA 提供了新的方法。此外，在辅助生殖中，对于胚胎的选择和子宫内膜容受性的预测，它们可以作为非侵入性的生物标志物，在减少组织机械损伤的过程中提高准确性。
关键词: 胚胎植入、非编码 RNA、microRNA、外泌体、胚细胞、microRNA 生物发生。
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DOI https://dx.doi.org/10.2174/1566524021666210526162917	Print ISSN 1566-5240
Publisher Name Bentham Science Publisher	Online ISSN 1875-5666
当代分子医药

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