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ISSN (Online): 1875-5607

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Review Article

Structure, Biological Activities and Metabolism of Flavonoid Glucuronides

Author(s): Min Chen*, Xueyang Ren*, Siqi Sun, Xiuhuan Wang, Xiao Xu, Xiang Li, Xiaoping Wang, Xiao Li, Xin Yan, Ruiwen Li, Yu Wang, Xiaoyun Liu, Ying Dong, Xueyan Fu and Gaimei She*

Volume 22, Issue 2, 2022

Published on: 21 May, 2021

Page: [322 - 354] Pages: 33

DOI: 10.2174/1389557521666210521221352

Price: $65

Abstract

Background: Flavonoid glucuronides are a kind of natural products presenting a flavone linked directly with one or several glucuronides through O-glycoside bond. They had become of interest in natural product research in the past decades for their antioxidant, anti-inflammatory, and antibacteria activities. In particular, the compound breviscapine has a notable effect on cardiocerebrovascular diseases. Several other compounds even have antitumor activity.

Methods: Through searching the database and reading a large number of documents, we summarized the related findings of flavonoid glucuronides.

Results: We summarized 211 naturally occurring flavonoid glucuronides in 119 references with their chemical structures, biological activities, and metabolism. A total of 220 references from 1953 to 2020 were cited in this paper according to literature databases such as CNKI, Weipu, Wanfang data, Elsevier, Springer, Wiley, NCBI, PubMed, EmBase, etc.

Conclusion: Flavonoid glucuronides are a class of compounds with various chemical structures and a diverse range of biological activities. They are thought to be potential candidates for drug discovery, but the specific study on their mechanisms is still limited until now. We hope this article can provide references for natural product researchers and draw more attention to flavonoid glucuronides’ biological activities and mechanisms.

Keywords: Flavonoid glucuronides, traditional chinese medicine, phytochemistry, chemical constituents, biological activity, metabolism.

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