A Possible Placental Factor for Preeclampsia: sFlt-1

Title: A Possible Placental Factor for Preeclampsia: sFlt-1

Volume: 15 Issue: 7

Author(s): Naoko Kita and Junji Mitsushita

Affiliation:

Keywords: Preeclampsia, sFlt-1, PlGF, VEGF, hypoxia

Abstract: Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its overexpression leads to preeclampsia-like symptoms.

Cite this article as:

Kita Naoko and Mitsushita Junji, A Possible Placental Factor for Preeclampsia: sFlt-1, Current Medicinal Chemistry 2008; 15 (7) . https://dx.doi.org/10.2174/092986708783885309