调节炎症相关的铁死亡——帕金森病的治疗策略

Title:Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease

Volume: 28 Issue: 33

关键词: 铁死亡、帕金森病、铁积累、炎症、神经变性、药物。

摘要: Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic reasons for PD, it’s underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson’s disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders, including PD. We have also discussed the unique features of ferroptosis , and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.

Cite this article as:

Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease, Current Medicinal Chemistry 2021; 28 (33) . https://dx.doi.org/10.2174/0929867328666210419125032