Abstract
Spiraling drug developmental costs and lengthy time-to-market introduction are two critical challenges facing the pharmaceutical industry. The clinical trials success rate for oncology drugs is reported to be 5% as compared to other therapeutic categories (11%) with most failures often encountered late in the clinical development process. PET and SPECT nuclear imaging technologies could play an important role in facilitating the drug development process improving the speed, efficiency and cost of drug development. This review will focus on recent studies of PET and SPECT radioligands in oncology and their application in the investigation of tumor biology. The use of clinically-validated radioligands as imaging-based biomarkers in oncology could significantly impact new cancer therapeutic development.
Keywords: PET, SPECT, radioligands, tumor imaging, tumor biomarkers, drug development
Current Computer-Aided Drug Design
Title: PET and SPECT Imaging of Tumor Biology: New Approaches Towards Oncology Drug Discovery and Development
Volume: 4 Issue: 1
Author(s): Marcian E. Van Dort, Alnawaz Rehemtulla and Brian D. Ross
Affiliation:
Keywords: PET, SPECT, radioligands, tumor imaging, tumor biomarkers, drug development
Abstract: Spiraling drug developmental costs and lengthy time-to-market introduction are two critical challenges facing the pharmaceutical industry. The clinical trials success rate for oncology drugs is reported to be 5% as compared to other therapeutic categories (11%) with most failures often encountered late in the clinical development process. PET and SPECT nuclear imaging technologies could play an important role in facilitating the drug development process improving the speed, efficiency and cost of drug development. This review will focus on recent studies of PET and SPECT radioligands in oncology and their application in the investigation of tumor biology. The use of clinically-validated radioligands as imaging-based biomarkers in oncology could significantly impact new cancer therapeutic development.
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Cite this article as:
Van Dort E. Marcian, Rehemtulla Alnawaz and Ross D. Brian, PET and SPECT Imaging of Tumor Biology: New Approaches Towards Oncology Drug Discovery and Development, Current Computer-Aided Drug Design 2008; 4 (1) . https://dx.doi.org/10.2174/157340908783769265
DOI https://dx.doi.org/10.2174/157340908783769265 |
Print ISSN 1573-4099 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6697 |
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