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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Use of 3-(Pentafluorosulfanyl)phenol to Access to Advanced Substituted Pentafluorosulfanylphenol/anisole: Application to the Synthesis of 2-(Arylpentafluorosulfanyl)indanedione

Author(s): Antoine Michaut*, Sabrina Quatrevaux, Laurence Queguiner, Sandrine Gaurrand and Jérôme Guillemont

Volume 19, Issue 8, 2022

Published on: 19 March, 2022

Page: [602 - 607] Pages: 6

DOI: 10.2174/1570178618666210218211831

Price: $65

Abstract

The synthesis of advanced substituted 3-pentafluorosulfanylphenol/anisole was accomplished starting from the easy to access and commercially available 3-pentafluorosulfanylphenol. These products bear diverse substitutions such as ester, aldehyde, halogens, alcohol, nitrile and carboxylic acid and could be in the future used as high-value building blocks for the synthesis of various scaffolds. For our part, this intermediate had been used to synthesize a library of 2-arylindadiones substituted by a pentafluorosulfanyl group.

Keywords: SF5, pentafluorosulfanyl, indanedione, anisole, phenol, building blocks.

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