The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy

Title:The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy

Volume: 22 Issue: 13

Author(s): Arezoo G. Shabgah, Hamed Mohammadi, Pouya Goleij, Mahdiyeh Hedayati-Moghadam, Arash Salmaninejad and Jamshid G. Navashenaq*

Affiliation:

• Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam,Iran

Keywords: Non-coding RNA, miRNA, lncRNA, cancer, cancer-associated fibroblasts, fibroblasts.

Abstract: Cancer-associated fibroblasts (CAFs) are senescent fibroblasts in tumor nest, which trigger a signaling center to remodel a desmoplastic tumor niche. CAF’s functions in cancer are closely similar to myofibroblasts during the wound healing process. They can produce cytokines, enzymes, and protein- or RNA-containing exosomes to alter the function of surrounding cells. Non-- coding RNAs, including microRNAs and long non-coding RNAs, modulate pathologic mechanisms in cancer. Dysregulation of these RNAs influences the formation and function of CAFs. Furthermore, it has been demonstrated that CAFs, by releasing non-coding RNAs-containing exosomes, affect the tumor cells’ behavior. CAFs also secrete mediators such as chemokines to alter the expression of non-coding RNAs in the tumor microenvironment. This study aimed to discuss the role of non-coding RNAs in CAF development in cancer. Additionally, we have shed light on the therapeutic approaches to develop the strategies based on the alteration of non-coding RNAs in cancer.

Cite this article as:

Shabgah G. Arezoo , Mohammadi Hamed , Goleij Pouya , Hedayati-Moghadam Mahdiyeh , Salmaninejad Arash and Navashenaq G. Jamshid *, The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy, Current Drug Targets 2021; 22 (13) . https://dx.doi.org/10.2174/1389450122666210216091953