The Involvement of Histone Methylation in the Osteogenic Differentiation of Mesenchymal Stem Cells

Title:The Involvement of Histone Methylation in the Osteogenic Differentiation of Mesenchymal Stem Cells

Volume: 16 Issue: 8

Author(s): Lingyi Zhao, Bei Yin, Qingge Ma, Yu Shi, Chenglin Wang and Ling Ye*

Affiliation:

• Department of Endodontics, West China School of Stomatology, Sichuan University, Chengdu,China

Keywords: Cell differentiation, mesenchymal stem cells, epigenetics, osteogenesis, histone methylation, osteogenic differentiation.

Abstract: Bone is a hard but dynamic organ that is constantly remodeled throughout the life process. The dynamic balance between bone resorption and bone formation is very important. Mesenchymal stem cells (MSCs) have self-renewal and pluripotent differentiation; therefore, their roles as the promising tool for the treatment of osteoporosis and other diseases have become the focus in regenerative medicine in recent years. Over the past years, histone methylation has been recognized as a major player in the regulation of osteogenic differentiation of MSC. In this review, we highlight the recent research progress of histone methylation modification and its possible involvement in MSC osteogenesis.

Cite this article as:

Zhao Lingyi, Yin Bei, Ma Qingge, Shi Yu, Wang Chenglin and Ye Ling*, The Involvement of Histone Methylation in the Osteogenic Differentiation of Mesenchymal Stem Cells, Current Stem Cell Research & Therapy 2021; 16 (8) . https://dx.doi.org/10.2174/1574888X16666210203110354