骨骼肌萎缩中 Toll 样受体信号的动力学

Title:Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy

Volume: 28 Issue: 28

关键词: Toll 样受体、骨骼肌萎缩、炎症、氧化应激、促炎细胞因子。

摘要: Skeletal muscle atrophy has been characterized as a state of uncontrolled inflammation and oxidative stress that escalates protein catabolism. Recent advancement supports impinging signaling molecules in the muscle fibers controlled through toll-like receptors (TLR). Activated TLR signaling pathways have been identified as inhibitors of muscle mass and provoke the settings for muscle atrophy. Among them, mainly TLR2 and TLR4 manifest their presence to exacerbate the release of the pro-inflammatory cytokine to deform the synchronized muscle programming. The present review enlightens the TLR signaling mediated muscle loss and the interplay between inflammation and skeletal muscle growth.

Cite this article as:

Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy, Current Medicinal Chemistry 2021; 28 (28) . https://dx.doi.org/10.2174/0929867328666210202113734