Biologically Responsive Nanosystems Targeting Cardiovascular Diseases

Title:Biologically Responsive Nanosystems Targeting Cardiovascular Diseases

Volume: 18 Issue: 7

Author(s): Zhiling Song, Kechen Song, Yi Xiao, Hui Guo, Yizhun Zhu*Xiaolin Wang*

Affiliation:

• State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Taipa, Macao,China

• State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Taipa, Macao,China

Keywords: Biologically responsive, nanosystems, nanoparticle, drug delivery, stimuli-triggered drug release, cardiovascular diseases.

Abstract: Cardiovascular Diseases (CVD) remain the leading cause of mortality and morbidity worldwide. To date, significant progress has been made in developing stimuli-responsive nanosystems that can intrinsically interact with pathological microenvironment to achieve site-specific delivery along with on-demand drug release for precise CVD treatment. Herein, this review summarizes recent advances on smart nanosystems in response to a wide range of biological cues, including pH, enzymes, ROS, shear force, ATP, etc., which can boost drug delivery performance or monitor disease progression in a non-invasive manner. The designs, compositions and main outcomes of the single and multi-responsive nanosystems for drug delivery and/or detection purposes are provided and discussed.

Cite this article as:

Song Zhiling , Song Kechen , Xiao Yi , Guo Hui , Zhu Yizhun *, Wang Xiaolin *, Biologically Responsive Nanosystems Targeting Cardiovascular Diseases, Current Drug Delivery 2021; 18 (7) . https://dx.doi.org/10.2174/1567201818666210127093743