黄酮类化合物对阿尔茨海默病线粒体功能障碍的修正作用

Title:Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction

Volume: 22 Issue: 14

关键词: 类黄酮、阿尔茨海默病、线粒体功能障碍、活性氧、β-淀粉样蛋白、色烯类似物。

摘要: Flavonoids are chromene analogues abundantly found in plants. It has always been of interest to discover natural flavonoid structures, since living things, including humans, are routinely exposed to these compounds through many dietaries. So far, numerous studies have been conducted on flavonoids with diverse biological actions. The activity results obtained, particularly regarding the effects of flavonoids on various validated and non-validated targets of Alzheimer’s Disease (AD), make these compounds promising agents either to be directly employed in clinical trials or to be utilized as important scaffolds for flavonoid-based drug design studies. Although there are many review articles on the treatment and protective effects of flavonoids on AD, within this review, the effects of flavonoids on mitochondrial dysfunction developing throughout AD have been presented concomitant to their structural organization.

Cite this article as:

Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction, Current Drug Targets 2021; 22 (14) . https://dx.doi.org/10.2174/1389450122666210120144921