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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Letter Article

Iso-octenidine: Promising Octenidine Analogue with Improved Solubility

Author(s): Igor K. Yakuschenko, Nataliya N. Pozdeeva, Viktoriya A. Mumyatova, Alexey A. Terentiev and Svyatoslav Ya. Gadomsky*

Volume 18, Issue 5, 2021

Published on: 31 December, 2020

Page: [443 - 445] Pages: 3

DOI: 10.2174/1570179417666201231104453

Price: $65

Abstract

Iso-octenidine, an isomer of octenidine dihydrochloride, was synthesized and studied for the first time. Iso-octenidine was demonstrated to be 3-fold more soluble in water in comparison to original octenidine, and both substances had remarkably similar antibacterial activity (tested on Escherichia Coli and Micrococcus luteus).

Keywords: Octenidine dihydrochloride, bispyridinium salts, alkylation reaction, organic synthesis, solubility, antibacterial activity.

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