Leptin: A Promising Therapeutic Target with Pleiotropic Action Besides Body Weight Regulation

Title: Leptin: A Promising Therapeutic Target with Pleiotropic Action Besides Body Weight Regulation

Volume: 7 Issue: 6

Author(s): Kosmas I. Paraskevas, Christos D. Liapis and Dimitri P. Mikhailidis

Affiliation:

Keywords: Leptin, vascular biology, vascular disease, renal disease, fertility

Abstract: Leptin seems to regulate various physiological mechanisms besides body weight. Leptin plays a role in vascular biology and pathology as well as renal function. In addition, leptin has been implicated in the regulation of fertility and reproduction. The effect of pharmaceutical agents on circulating plasma leptin levels has been assessed. Among the drugs investigated are glitazones, statins, fibrates, serotonin reuptake inhibitors and cannabinoid-1 receptor antagonists. Since these agents are used to treat pathological conditions there is a potential role for leptin in these states. The degree of involvement of leptin in several pathophysiological states needs to be defined to aid in the development of potentially useful therapeutic agents.

Cite this article as:

Paraskevas I. Kosmas, Liapis D. Christos and Mikhailidis P. Dimitri, Leptin: A Promising Therapeutic Target with Pleiotropic Action Besides Body Weight Regulation, Current Drug Targets 2006; 7 (6) . https://dx.doi.org/10.2174/138945006777435371