新型 HDAC6 异构体选择性抑制剂的最新进展

Title:Recent Development of Novel HDAC6 Isoform-selective Inhibitors

Volume: 28 Issue: 21

关键词: 转录后修饰，HDAC6，结构，癌症，选择性抑制剂，组蛋白去乙酰化。

摘要: As an important post-transcription modification, histone deacetylation plays significant roles in chromatin remodeling and gene expression. The aberrant modification of histone deacetylation leads to various diseases. As a critical member of histone deacetylase (HDAC), HDAC6 serves as a key modulator in many physiological processes. Abnormal expression of HDAC6 gives rise to cancer, neurodegeneration and other diseases. Here, we have reviewed recent advances in physiological, protein structure and development of HDAC6 selective inhibitors.

Cite this article as:

Recent Development of Novel HDAC6 Isoform-selective Inhibitors, Current Medicinal Chemistry 2021; 28 (21) . https://dx.doi.org/10.2174/0929867327666201111142653