HOX作为乳腺癌潜在治疗靶点的失调

Title:Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer

Volume: 28 Issue: 25

关键词: HOX基因，HOX簇，非编码RNA，基因组组织，3D结构，HOX蛋白，乳腺癌。

摘要: HOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer, where they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs embedded within the HOX cluster and the role of these molecules in breast cancer, have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.

Cite this article as:

Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867327666201102115327