The Mitochondrion-Targeted Antioxidants in Kidney Disease

Title:The Mitochondrion-Targeted Antioxidants in Kidney Disease

Volume: 28 Issue: 21

Author(s): Xinrui Li, Liang Ma*Ping Fu

Affiliation:

• Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041,China

Keywords: mitochondria-targeted, antioxidant, kidney disease, triphenylphosphonium, Szeto-Schiller peptides, hemigramicidin.

Abstract: Mitochondria are a potent source of cellular reactive oxygen species (ROS) and are vulnerable to oxidative damage. Mitochondria dysfunction could result in adenosine triphosphate (ATP) decrease and cell death. The kidney is an ATP-consuming organ, and the relationship between mitochondrial dysfunction and renal disease has been long noted. Mitochondrial targeting is a novel strategy for kidney diseases. At present, there are several ways to target mitochondria, such as the addition of a triphenylphosphonium cation, mitochondria-targeted peptides, and nanocarrier. There are also a variety of choices for the payload, such as nitroxides, quinone derivates, vitamins and so on. This review summarized the chemical and also clinical characteristics of various mitochondria- targeted antioxidants and focused on their application and perspectives in kidney diseases.

Cite this article as:

Li Xinrui , Ma Liang *, Fu Ping , The Mitochondrion-Targeted Antioxidants in Kidney Disease, Current Medicinal Chemistry 2021; 28 (21) . https://dx.doi.org/10.2174/0929867327666201020151124