Synthetic Strategies for the (+)-Grandisol, the Main Constituent of Boll Weevil Pheromone

Title:Synthetic Strategies for the (+)-Grandisol, the Main Constituent of Boll Weevil Pheromone

Volume: 18 Issue: 6

Author(s): Krysthal Marrie dos Santos, Jorge de Lima Neto, Luis Paulo Alves da Silva, Analú Campos Reis, Ricardo Silva Porto, Dimas José da Paz Lima and Antônio Euzébio Goulart Santana*

Affiliation:

• Center of Engineering and Agrarian Science, Federal University of Alagoas, Rio Largo,Brazil

Keywords: Pheromone, (+)-grandisol, [2 + 2] cycloaddition, boll weevil, Anthonomus grandis Boh, cyclobutane ring systems.

Abstract: This paper presents a short review of synthetic approaches aiming to synthesise (+)- Grandisol, the main constituent of grandlure, a pheromone mixture released by the boll weevil, which is proven to exhibit significant biological activity. (+)-Grandisol 1 is among the components of the male-produced pheromone of the boll weevil Anthonomuns grandis, an important pest of cotton crops in Mesoamerica (from the south USA to Argentina). As a result of its biological activity and unique structure, several synthetic approaches have been reported. The aim is to explore remarkable methodologies towards the synthesis of (+)-Grandisol 1. Several methodologies have been applied towards the synthesis of (+)-Grandisol 1, including classical methods for cyclobutane ring construction, which promoted substantial improvements to access this pheromone, as well as a better comprehension of its biological profile.

Cite this article as:

dos Santos Marrie Krysthal , de Lima Neto Jorge , da Silva Paulo Alves Luis , Reis Campos Analú, Porto Silva Ricardo , da Paz Lima José Dimas and Santana Euzébio Goulart Antônio *, Synthetic Strategies for the (+)-Grandisol, the Main Constituent of Boll Weevil Pheromone, Mini-Reviews in Organic Chemistry 2021; 18 (6) . https://dx.doi.org/10.2174/1570193X17999200911113127