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Review Article

转移性结直肠癌中第二代抗EGFR单克隆抗体的研究进展

卷 22, 期 9, 2021

发表于: 27 July, 2020

页: [1034 - 1042] 页: 9

弟呕挨: 10.2174/1389450121666200727121011

价格: $65

摘要

背景：抗EGFR单克隆抗体已成为治疗转移性结直肠癌患者的相关解决方案。目前的抗EGFR单克隆抗体面临一系列问题，包括耐药性和不持久的反应，RAS和BRAF突变作为抗EGFR单克隆抗体治疗的排除标准。分子肿瘤谱的进展和导致疾病进展和耐药性的后续途径的信息有助于开发新一代抗EGFR单克隆抗体。这些第二代单克隆抗体的开发是为了克服现有的耐药机制并限制常见的副作用。目前，现有文献表明，这些新的抗EGFR单克隆抗体还远未找到临床应用的途径。 目的：在这篇综述中，我们总结和评价了关于不同的第二代抗EGFR单克隆抗体正在进行的研究和已完成的临床试验的当前数据。 结论：抗EGFR单克隆抗体对晚期结直肠癌有效，但第二代单克隆抗体未能证明其在转移性结直肠癌治疗中的益处。了解原发性和获得性耐药性的生物学基础可以让科学家设计更好的临床试验，开发改进的第二代单克隆抗体。

关键词: 结肠直肠癌，转移性，单克隆抗体，第二代，抗EGFR，治疗，药物靶点，试验。

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