The Multi Steps Synthetic Methods of (±)-Indolizidine 209D as an Amphibian Natural Product in the Family of Alkaloids

Title:The Multi Steps Synthetic Methods of (±)-Indolizidine 209D as an Amphibian Natural Product in the Family of Alkaloids

Volume: 11 Issue: 4

Author(s): Fatemeh Mohajer, Ghodsi Mohammadi Ziarani*Fatemeh Taghipour

Affiliation:

• Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Tehran,Iran

Keywords: (±)-Indolizidine 209D, amphibian natural product, alkaloid derivatives, poisonous frogs, biologically active compounds, alkaloid total synthesis.

Abstract: (±)-Indolizidine 209D is one of the alkaloids isolated from the skin secretions of certain neotropical frogs and exhibit a range of pharmacological properties, including blocking neuromuscular transmission. Therefore, the synthesis of indolizidine 209D and more complex derivatives, have been the subject of several publications. The preparation pathways of indolizidine 209D and its derivatives are the subject of this review. In this paper, some highly regio- and stereoselective functionalization process were reviewed through the synthesis of the optically active (±)-indolizidine 209D.

Cite this article as:

Mohajer Fatemeh , Ziarani Mohammadi Ghodsi *, Taghipour Fatemeh , The Multi Steps Synthetic Methods of (±)-Indolizidine 209D as an Amphibian Natural Product in the Family of Alkaloids, The Natural Products Journal 2021; 11 (4) . https://dx.doi.org/10.2174/2210315510999200607180544