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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Research Article

Highly Efficient Ultrasound Promoted Synthesis of 2-phenylquinoxaline in Glycerol- Water

Author(s): Mujahed Shaikh*, Devendra Wagare, Ashvini Sonone and Ayesha Durrani

Volume 17, Issue 6, 2020

Page: [483 - 487] Pages: 5

DOI: 10.2174/1570179417666200529121602

Abstract

Introduction: Quinoxalines show diversified applications in the field of medicinal chemistry.

Materials and Methods: Therefore, we have designed a highly efficient, environmentally benign and one-pot protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and 1,2-phenylenediamine under ultrasound irradiation in glycerol-water.

Results and Discussion: We observed that, although the reaction efficiently completed in all of these solvents, the use of glycerol-water with different ratios gives consistently higher yields (89–94%) and decreases reaction times.

Conclusion: The main advantages of this protocol are that it is a green method, avoids the use of toxic catalysts and volatile organic medium and the product is obtained with excellent yield.

Keywords: O-Phenylenediamine, Acetophenone, Trimethylsilyl Chloride, Glycerol, Ultrasound, N-bromosuccinimide.

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