Systematic Review Article

镓化合物抗炎作用的系统综述

卷 28, 期 10, 2021

发表于: 25 May, 2020

页: [2062 - 2076] 页: 15

弟呕挨: 10.2174/0929867327666200525160556

价格: $65

摘要

背景:炎症是免疫系统提供的一种必要的反应,确保在微生物感染、组织损伤和其他有害条件下生存。然而,长期的炎症过程往往会对健康产生严重的副作用。 目的:本系统综述旨在提供2000年至2019年镓化合物临床前和人体抗炎活性的文献证据,重点阐明炎症过程中所涉及的机制。 方法:检索了7个书目数据库(PubMed、Medline、ScienceDirect、Scopus、施普林格、Web of Science和EBSCOhost)。根据PRISMA声明中提到的指导方针,选择适当的出版物和编写系统的审查。此外,对所选研究的方法学质量进行了评价。 结果:在总共3018项研究中,根据我们的资格标准,有16项研究被纳入了本文,这些研究显示了有希望和一致的结果。 结论:需要对特定的炎症条件进行进一步研究。

关键词: 镓堆肥,炎症,促炎症介质,再生,药物化学,无机化合物

[1]
Bernstein, L.R. Mechanisms of therapeutic activity for gallium. Pharmacol. Rev., 1998, 50(4), 665-682.
[PMID: 9860806]
[2]
Chitambar, C.R. The therapeutic potential of iron-targeting gallium compounds in human disease: from basic research to clinical application. Pharmacol. Res., 2017, 115, 56-64.
[http://dx.doi.org/10.1016/j.phrs.2016.11.009] [PMID: 27856328]
[3]
Chitambar, C.R. Gallium-containing anticancer compounds. Future Med. Chem., 2012, 4(10), 1257-1272.
[http://dx.doi.org/10.4155/fmc.12.69] [PMID: 22800370]
[4]
Bernstein, L.R.; Tanner, T.; Godfrey, C.; Noll, B. Chemistry and pharmacokinetics of gallium maltolate, a compound with high oral gallium bioavailability. Met. Based Drugs, 2000, 7(1), 33-47.
[http://dx.doi.org/10.1155/MBD.2000.33] [PMID: 18475921]
[5]
Whitacre, C.; Apseloff, G.; Cox, K.; Matkovic, V.; Jewell, S.; Gerber, N. Suppression of experimental autoimmune encephalomyelitis by gallium nitrate. J. Neuroimmunol., 1992, 39(1-2), 175-181.
[http://dx.doi.org/10.1016/0165-5728(92)90186-O] [PMID: 1377710]
[6]
Huang, E.H.; Gabler, D.M.; Krecic, M.E.; Gerber, N.; Ferguson, R.M.; Orosz, C.G. Differential effects of gallium nitrate on T lymphocyte and endothelial cell activation. Transplantation, 1994, 58(11), 1216-1222.
[PMID: 7992366]
[7]
Kovar, J.; Seligman, P.; Gelfand, E.W. Differential growth-inhibitory effects of gallium on B-lymphocyte lines in high versus low iron concentrations. Cancer Res., 1990, 50(18), 5727-5730.
[PMID: 2393846]
[8]
Drobyski, W.R.; Ul-Haq, R.; Majewski, D.; Chitambar, C.R. Modulation of in vitro and in vivo T-cell responses by transferrin-gallium and gallium nitrate. Blood, 1996, 88(8), 3056-3064.
[http://dx.doi.org/10.1182/blood.V88.8.3056.bloodjournal8883056] [PMID: 8874204]
[9]
Matkovic, V.; Balboa, A.; Clinchot, D.; Whitacre, C.; Zwilling, B.; Brown, D. Gallium prevents adjuvant arthritis in rats and interferes with macrophage/T-cell function in the immune response. Curr. Ther. Res. Clin. Exp., 1991, 50(2), 255-267.
[10]
Apseloff, G.; Hackshaw, K.V.; Whitacre, C.; Weisbrode, S.E.; Gerber, N. Gallium nitrate suppresses lupus in MRL/lpr mice. Naunyn Schmiedebergs Arch. Pharmacol., 1997, 356(4), 517-525.
[http://dx.doi.org/10.1007/PL00005085] [PMID: 9349640]
[11]
Orosz, C.G.; Wakely, E.; Bergese, S.D.; VanBuskirk, A.M.; Ferguson, R.M.; Mullet, D.; Apseloff, G.; Gerber, N. Prevention of murine cardiac allograft rejection with gallium nitrate. Comparison with anti-CD4 monoclonal antibody. Transplantation, 1996, 61(5), 783-791.
[http://dx.doi.org/10.1097/00007890-199603150-00019] [PMID: 8607184]
[12]
Lobanoff, M.C.; Kozhich, A.T.; Mullet, D.I.; Gerber, N.; Gery, I.; Chan, C.C.; Whitcup, S.M. Effect of gallium nitrate on experimental autoimmune uveitis. Exp. Eye Res., 1997, 65(6), 797-801.
[http://dx.doi.org/10.1006/exer.1997.0395] [PMID: 9441703]
[13]
Matkovic, V.; Apseloff, G.; Shepard, D.R.; Gerber, N. Use of gallium to treat Paget’s disease of bone: a pilot study. Lancet, 1990, 335(8681), 72-75.
[http://dx.doi.org/10.1016/0140-6736(90)90540-L] [PMID: 1967419]
[14]
Makkonen, N.; Hirvonen, M.-R.; Savolainen, K.; Lapinjoki, S.; Mönkkönen, J. The effect of free gallium and gallium in liposomes on cytokine and nitric oxide secretion from macrophage-like cells in vitro. Inflamm. Res., 1995, 44(12), 523-528.
[http://dx.doi.org/10.1007/BF01757356] [PMID: 8788232]
[15]
Mullet, D.; Bian, X.; Cox, G.W.; Zaveri, N.; Gerber, N.; Fertel, R.H. Gallium nitrate inhibits nitric acid production by activated ANA-1 macrophages. FASEB J., 1995, 9, A944.
[16]
Chitambar, C.R. Medical applications and toxicities of gallium compounds. Int. J. Environ. Res. Public Health, 2010, 7(5), 2337-2361.
[http://dx.doi.org/10.3390/ijerph7052337] [PMID: 20623028]
[17]
Wessling-Resnick, M. Iron homeostasis and the inflammatory response. Annu. Rev. Nutr., 2010, 30, 105-122.
[http://dx.doi.org/10.1146/annurev.nutr.012809.104804] [PMID: 20420524]
[18]
Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D.G. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann. Intern. Med., 2009, 151(4), 264-269.
[http://dx.doi.org/10.7326/0003-4819-151-4-200908180-00135] [PMID: 19622511]
[19]
Schneider, K.; Schwarz, M.; Burkholder, I.; Kopp-Schneider, A.; Edler, L.; Kinsner-Ovaskainen, A.; Hartung, T.; Hoffmann, S. “ToxRTool”, a new tool to assess the reliability of toxicological data. Toxicol. Lett., 2009, 189(2), 138-144.
[http://dx.doi.org/10.1016/j.toxlet.2009.05.013] [PMID: 19477248]
[20]
Murad, M.H.; Sultan, S.; Haffar, S.; Bazerbachi, F. Methodological quality and synthesis of case series and case reports. BMJ Evid. Based Med., 2018, 23(2), 60-63.
[http://dx.doi.org/10.1136/bmjebm-2017-110853] [PMID: 29420178]
[21]
Akira, S.; Uematsu, S.; Takeuchi, O. Pathogen recognition and innate immunity. Cell, 2006, 124(4), 783-801.
[http://dx.doi.org/10.1016/j.cell.2006.02.015] [PMID: 16497588]
[22]
Fujiwara, N.; Kobayashi, K. Macrophages in inflammation. Curr. Drug Targets Inflamm. Allergy, 2005, 4(3), 281-286.
[http://dx.doi.org/10.2174/1568010054022024] [PMID: 16101534]
[23]
Bibi, H.; Vinokur, V.; Waisman, D.; Elenberg, Y.; Landesberg, A.; Faingersh, A.; Yadid, M.; Brod, V.; Pesin, J.; Berenshtein, E.; Eliashar, R.; Chevion, M. Zn/Ga-DFO iron-chelating complex attenuates the inflammatory process in a mouse model of asthma. Redox Biol., 2014, 2(1), 814-819.
[http://dx.doi.org/10.1016/j.redox.2014.06.009] [PMID: 25009783]
[24]
Sahiner, U.M.; Birben, E.; Erzurum, S.; Sackesen, C.; Kalayci, O. Oxidative stress in asthma. World Allergy Organ. J., 2011, 4(10), 151-158.
[http://dx.doi.org/10.1097/WOX.0b013e318232389e] [PMID: 23268432]
[25]
Dong, J.; Fang, D.; Zhang, L.; Shan, Q.; Huang, Y. Gallium-doped titania nanotubes elicit anti-bacterial efficacy in vivo against Escherichia coli and Staphylococcus aureus biofilm. Materialia., 2019, 5, 100209.
[http://dx.doi.org/10.1016/j.mtla.2019.100209]
[26]
Epstein, H.; Berger, V.; Levi, I.; Eisenberg, G.; Koroukhov, N.; Gao, J.; Golomb, G. Nanosuspensions of alendronate with gallium or gadolinium attenuate neointimal hyperplasia in rats. J. Control. Release, 2007, 117(3), 322-332.
[http://dx.doi.org/10.1016/j.jconrel.2006.10.030] [PMID: 17234295]
[27]
House, S.D.; Guidon, P.T. Jr.; Perdrizet, G.A.; Rewinski, M.; Kyriakos, R.; Bockman, R.S.; Mistry, T.; Gallagher, R.A.; Hightower, L.E. Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response. Cell Stress Chaperones, 2001, 6(2), 164-171.
[http://dx.doi.org/10.1379/1466-1268(2001)006<0164: EOHSSC>2.0.CO;2] [PMID: 11599578]
[28]
Thompson, M.G.; Truong-Le, V.; Alamneh, Y.A.; Black, C.C.; Anderl, J.; Honnold, C.L.; Pavlicek, R.L.; Abu-Taleb, R.; Wise, M.C.; Hall, E.R.; Wagar, E.J.; Patzer, E.; Zurawski, D.V. Evaluation of gallium citrate formulations against a multidrug-resistant strain of Klebsiella pneumoniae in a murine wound model of infection. Antimicrob. Agents Chemother., 2015, 59(10), 6484-6493.
[http://dx.doi.org/10.1128/AAC.00882-15] [PMID: 26239978]
[29]
Verri, W.A. Jr.; Cunha, T.M.; Poole, S.; Ferreira, S.H.; Cunha, F.Q. Cytokine inhibitors and pain control. Rev. Bras. Reumatol., 2007, 47(5), 341-353.
[http://dx.doi.org/10.1590/S0482-50042007000500009]
[30]
Moss, J.W.; Ramji, D.P. Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets. Future Med. Chem., 2016, 8(11), 1317-1330.
[http://dx.doi.org/10.4155/fmc-2016-0072] [PMID: 27357616]
[31]
Choi, J.H.; Lee, J.H.; Roh, K.H.; Seo, S.K.; Choi, I.W.; Park, S.G.; Lim, J.G.; Lee, W.J.; Kim, M.H.; Cho, K.R.; Kim, Y.J. Gallium nitrate ameliorates type II collagen-induced arthritis in mice. Int. Immunopharmacol., 2014, 20(1), 269-275.
[http://dx.doi.org/10.1016/j.intimp.2014.03.005] [PMID: 24656780]
[32]
Wang, J.; He, M.; Wang, G.; Fu, Q. Organic gallium treatment improves osteoporotic fracture healing through affecting the OPG/RANKL ratio and expression of serum inflammatory cytokines in ovariectomized rats. Biol. Trace Elem. Res., 2018, 183(2), 270-279.
[http://dx.doi.org/10.1007/s12011-017-1123-y] [PMID: 28836172]
[33]
Joosten, L.A.B.; Crişan, T.O.; Azam, T.; Cleophas, M.C.; Koenders, M.I.; van de Veerdonk, F.L.; Netea, M.G.; Kim, S.; Dinarello, C.A. Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra. Ann. Rheum. Dis., 2016, 75(6), 1219-1227.
[http://dx.doi.org/10.1136/annrheumdis-2014-206966] [PMID: 26174021]
[34]
Panagakos, F.S.; Kumar, E.; Venescar, C.; Guidon, P. The effect of gallium nitrate on synoviocyte MMP activity. Biochimie, 2000, 82(2), 147-151.
[http://dx.doi.org/10.1016/S0300-9084(00)00384-9] [PMID: 10727770]
[35]
Choi, S.R.; Britigan, B.E.; Narayanasamy, P. Treatment of virulent Mycobacterium tuberculosis and HIV coinfected macrophages with gallium nanoparticles inhibits pathogen growth and modulates macrophage cytokine production. MSphere, 2019, 4(4), 1-11.
[http://dx.doi.org/10.1128/mSphere.00443-19] [PMID: 31341073]
[36]
Bickerstaff, A.A.; Wang, J.J.; Pelletier, R.P.; Orosz, C.G. The graft helps to define the character of the alloimmune response. Transpl. Immunol., 2002, 9(2-4), 137-141.
[http://dx.doi.org/10.1016/S0966-3274(02)00036-9] [PMID: 12180821]
[37]
Wu, X.; Wang, T.W.; Lessmann, G.M.; Saleh, J.; Liu, X.; Chitambar, C.R.; Hwang, S.T. Gallium maltolate inhibits human cutaneous T-cell lymphoma tumor development in mice. J. Invest. Dermatol., 2015, 135(3), 877-884.
[http://dx.doi.org/10.1038/jid.2014.476] [PMID: 25371972]
[38]
English, W.R.; Puente, X.S.; Freije, J.M.; Knauper, V.; Amour, A.; Merryweather, A.; Lopez-Otin, C.; Murphy, G. Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2. J. Biol. Chem., 2000, 275(19), 14046-14055.
[http://dx.doi.org/10.1074/jbc.275.19.14046] [PMID: 10799478]
[39]
Mohan, M.J.; Seaton, T.; Mitchell, J.; Howe, A.; Blackburn, K.; Burkhart, W.; Moyer, M.; Patel, I.; Waitt, G.M.; Becherer, J.D.; Moss, M.L.; Milla, M.E. The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. Biochemistry, 2002, 41(30), 9462-9469.
[http://dx.doi.org/10.1021/bi0260132] [PMID: 12135369]
[40]
Navarro, V.P.; Nelson Filho, P.; Silva, L.A.B.; Freitas, A.C. The participation of matrix metalloproteinases in the physiopathological processes of the oral cavity. Rev. Odontol., 2006, 35(4), 233-238.
[41]
Manicone, A.M.; McGuire, J.K. Matrix metalloproteinases as modulators of inflammation. Semin. Cell Dev. Biol., 2008, 19(1), 34-41.
[http://dx.doi.org/10.1016/j.semcdb.2007.07.003] [PMID: 17707664]
[42]
Johansson, N.; Ahonen, M.; Kähäri, V.M. Matrix metalloproteinases in tumor invasion. Cell. Mol. Life Sci., 2000, 57(1), 5-15.
[http://dx.doi.org/10.1007/s000180050495] [PMID: 10949577]
[43]
Sahdev, R.; Ansari, T.I.; Higham, S.M.; Valappil, S.P. Potential use of gallium-doped phosphate-based glass material for periodontitis treatment. J. Biomater. Appl., 2015, 30(1), 85-92.
[http://dx.doi.org/10.1177/0885328215571952] [PMID: 25681404]
[44]
Xue, M.; McKelvey, K.; Shen, K.; Minhas, N.; March, L.; Park, S.Y.; Jackson, C.J. Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology (Oxford), 2014, 53(12), 2270-2279.
[http://dx.doi.org/10.1093/rheumatology/keu254] [PMID: 24982240]
[45]
Silva, D.C.; Cerchiaro, G.; Honório, K.M. Pathophysiologic relationships between oxidative stress and atherosclerosis. Quim. Nova, 2011, 34(2), 300-305.
[http://dx.doi.org/10.1590/S0100-40422011000200024]
[46]
Vellosa, J.C.R.; Parabocz, G.C.; Manente, F.A.; Ribas, J.T.; Lima, L.W. Alterações metabólicas e inflamatórias em condições de estresse oxidativo. Rev. Cienc. Farm. Basica Apl., 2013, 34(3), 305-312.
[47]
Banin, E.; Morad, Y.; Berenshtein, E.; Obolensky, A.; Yahalom, C.; Goldich, J.; Adibelli, F.M.; Zuniga, G.; DeAnda, M.; Pe’er, J.; Chevion, M. Injury induced by chemical warfare agents: characterization and treatment of ocular tissues exposed to nitrogen mustard. Invest. Ophthalmol. Vis. Sci., 2003, 44(7), 2966-2972.
[http://dx.doi.org/10.1167/iovs.02-1164] [PMID: 12824239]
[48]
Ricciotti, E.; FitzGerald, G.A. Prostaglandins and inflammation. Arterioscler. Thromb. Vasc. Biol., 2011, 31(5), 986-1000.
[http://dx.doi.org/10.1161/ATVBAHA.110.207449] [PMID: 21508345]
[49]
Campos, A.C.L.; Borges-Branco, A.; Groth, A.K. Cicatrização de feridas. Arq. Bras. Cir. Dig., 2007, 20(1), 51-58.
[http://dx.doi.org/10.1590/S0102-67202007000100010]
[50]
Pinho-Ribeiro, F.A.; Verri, W.A. Jr.; Chiu, I.M. Nociceptor sensory neuron-immune interactions in pain and inflammation. Trends Immunol., 2017, 38(1), 5-19.
[http://dx.doi.org/10.1016/j.it.2016.10.001] [PMID: 27793571]
[51]
Lorenz, M.D.; Coates, J.R.; Kent, M. Pain. Handbook of Veterinary Neurology; Elsevier, 2011, Vol. 5, pp. 413-431.
[http://dx.doi.org/10.1016/B978-1-4377-0651-2.10014-1]
[52]
Waljee, A.K.; Rogers, M.A.M.; Lin, P.; Singal, A.G.; Stein, J.D.; Marks, R.M.; Ayanian, J.Z.; Nallamothu, B.K. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ, 2017, 357, j1415.
[http://dx.doi.org/10.1136/bmj.j1415] [PMID: 28404617]
[53]
Bernstein, L.R.; van der Hoeven, J.J.M.; Boer, R.O. Hepatocellular carcinoma detection by gallium scan and subsequent treatment by gallium maltolate: rationale and case study. Anticancer. Agents Med. Chem., 2011, 11(6), 585-590.
[http://dx.doi.org/10.2174/187152011796011046] [PMID: 21554205]
[54]
Bernstein, L.R. Successful treatment of refractory postherpetic neuralgia with topical gallium maltolate: case report. Pain Med., 2012, 13(7), 915-918.
[http://dx.doi.org/10.1111/j.1526-4637.2012.01404.x] [PMID: 22680305]
[55]
Eby, G. Elimination of arthritis pain and inflammation for over 2 years with a single 90 min, topical 14% gallium nitrate treatment: case reports and review of actions of gallium III. Med. Hypotheses, 2005, 65(6), 1136-1141.
[http://dx.doi.org/10.1016/j.mehy.2005.06.021] [PMID: 16122880]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy