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Review Article

酒精中毒和骨免疫学

卷 28, 期 9, 2021

发表于: 25 April, 2020

页: [1815 - 1828] 页: 14

弟呕挨: 10.2174/1567201816666190514101303

价格: $65

摘要

背景：长期饮酒对骨骼系统有不良影响，可能导致骨质疏松，骨折愈合延迟和股骨头坏死。当前，治疗是有限的，因此，迫切需要确定下划线机制并开发新的治疗方法。众所周知，正常的骨重塑依赖于破骨细胞介导的骨吸收与介导的骨形成之间的平衡。各种因素都可能破坏平衡，包括免疫系统功能障碍。在这篇综述中，我们总结了酒精性骨质减少的相关研究，重点是异常的骨免疫学信号。我们为酒精性骨的防治提供了新的理论依据。 方法：我们检索了1980年1月1日至2020年2月1日之间的PubMed出版物，以识别相关文献和近期文献，对酒精性骨质减少的评估和前景进行了总结。详细的搜索字词是“酒精”，“酒精性骨质疏松”，“酒精性骨质减少”，“免疫”，“骨免疫”，“骨重塑”，“骨质疏松治疗”和“骨质疏松治疗”。 结果：总共135篇论文被包括在评价中。大约60篇论文描述了酒精与骨骼重塑有关的机制。一些论文集中在通过骨免疫机制研究酒精在骨骼上的发病机理。 结论：酒精与骨骼重塑之间存在复杂的信号网络，骨免疫细胞间的通讯可能是酒精性骨骼的潜在机制。研究骨免疫机制对于酒精性骨疾病特有的药物开发至关重要。

关键词: 酒精，骨免疫学，骨骼重塑，骨质减少，氧化应激，炎症因子。

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