Review Article

心房利钠肽在精神病学中的新作用

卷 28, 期 1, 2021

发表于: 19 February, 2020

页: [69 - 79] 页: 11

弟呕挨: 10.2174/0929867327666200219091102

价格: $65

摘要

介绍:心房利钠肽(ANP),由28个氨基酸组成,是众所周知的调节液体和电解质稳态,下丘脑-垂体-肾上腺(HPA)轴活动和免疫系统。由于ANP同时在心脏和中枢神经系统(CNS)产生,近年来,人们越来越关注它在神经精神疾病中的可能作用。事实上,零散的数据表明它可能在焦虑、重度抑郁、成瘾行为、创伤后应激障碍和其他与压力相关的障碍中发挥作用。此外,ANP被认为是抑郁症与心血管健康和免疫系统相关的因素之一。 目的:鉴于现有信息的缺乏,本文的目的是回顾目前关于ANP在中枢神经系统和不同神经精神和应激相关疾病的病理生理学中的作用的文献。 讨论:精神疾病中ANP的支持数据仍然局限于动物研究,或者几十年前在患者身上收集的一些“真实”发现,这些发现应该在更大的临床样本中复制。 结论:需要进一步的研究来理解ANP在神经精神病学中的可能意义,因为它可能代表了在不同情况下创新精神药理治疗的新方法,所有这些都以HPA轴的过度活跃为基础。

关键词: 心房利钠肽,抑郁,焦虑障碍,创伤后应激障碍,精神分裂症,酗酒,ANP。

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