Co-existence of Follicular Lymphoma in the Lymph Node with High-grade B Cell Lymphoma in the Bone Marrow of a Patient with Spontaneous Tumor Lysis Syndrome

Title:Co-existence of Follicular Lymphoma in the Lymph Node with High-grade B Cell Lymphoma in the Bone Marrow of a Patient with Spontaneous Tumor Lysis Syndrome

Volume: 20 Issue: 3

Author(s): Chara Giatra, Alexandros G. Sykaras, Fotis Constantinou, Victoria Gennimata, Dimitrios Sampaziotis, Eleni Geladari, Dimitris Kounatidis and Natalia G. Vallianou*

Affiliation:

• Department of Internal Medicine, Evangelismos General Hospital, Athens,Greece

Keywords: High-grade B-cell lymphoma HGBL, follicular lymphoma FL, spontaneous tumor lysis syndrome, bone marrow transformation, lymph node.

Abstract: A significant percentage of B-cell lymphomas are characterized by bone marrow involvement (BMI) at diagnosis. In most cases, there is a concordance between the type of lymphoma present in the lymph node and the lymphoma present in the bone marrow. Herein, we presented a sixty-seven years old female patient, who was diagnosed with High-Grade B-cell Lymphoma (HGBL) in the bone marrow, while simultaneously, in the peripheral lymph node, the presence of Follicular Lymphoma (FL) was noted. The patient was presented to the hospital with spontaneous tumor lysis syndrome, a finding compatible with the aggressive course of the HGBL. To our knowledge, this is the first case of the co-existence of HGBL in the bone marrow and FL in a lymph node, which might be attributed to merely a coincidence or to the transformation of the cells in the preferable milieu of the bone marrow.

Cite this article as:

Giatra Chara , Sykaras G. Alexandros , Constantinou Fotis , Gennimata Victoria , Sampaziotis Dimitrios , Geladari Eleni , Kounatidis Dimitris and Vallianou G. Natalia *, Co-existence of Follicular Lymphoma in the Lymph Node with High-grade B Cell Lymphoma in the Bone Marrow of a Patient with Spontaneous Tumor Lysis Syndrome, Cardiovascular & Hematological Disorders-Drug Targets 2020; 20 (3) . https://dx.doi.org/10.2174/1871529X20666200130095417