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Mini-Review Article

NLRP3抑制剂的发现及其治疗潜力的研究进展

卷 28, 期 3, 2021

发表于: 23 January, 2020

页: [569 - 582] 页: 14

弟呕挨: 10.2174/0929867327666200123093544

价格: $65

摘要

背景：炎症是人体免疫系统对病原体、外部伤害、化学或辐射影响引起的刺激物的快速协调反应。NLRP3炎性小体是先天免疫系统的重要组成部分。NLRP3炎症小体的功能障碍与多种复杂疾病的发病机制有关，如无法控制的感染、自身免疫性疾病、神经退行性疾病和代谢紊乱。本文就NLRP3炎症小体抑制剂的发现及其治疗潜力的研究进展作一综述。 方法：根据NLRP3的激活机制，从NLRP3抑制剂的来源、结构、生物活性和作用机制等方面对几种NLRP3抑制剂进行了描述和总结。结构-活性关系(SAR)也列出了不同的支架，以及有效的药效基因。 结果：这篇综述包括了一百多篇论文。从2001年最早的格列本脲到2019年的最新进展，NLRP3抑制剂的发展已被描述。目前已对几种抑制剂进行了分类，如基于格列本脲的JC系列和基于2APB的BC系列。许多其他小分子，如NLRP3抑制剂也被列出。介绍了SAR在相关治疗模型中的应用，以及五种不同的作用机制。 结论：

关键词: NLRP3炎症小体，抑制剂，炎症性疾病，白细胞介素-1β，先天免疫，治疗潜力

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