Novel Aspects of Insulin-like Growth Factor 1/insulin Network in Chronic Inflammatory Airway Disease

doi:10.2174/0929867326666191113140826

摘要

至少一部分患有慢性炎症性气道疾病的患者对支气管扩张药和皮质类固醇疗法的反应较差。需要开发改进的抗炎治疗。胰岛素生长因子1（IGF1）和胰岛素不仅参与代谢和葡萄糖稳态，而且还参与许多其他生理和病理生理过程，包括生长和炎症。最近发现，不仅经典的IGF1和IGF1受体（IGF1R），而且IGF1 /胰岛素网络中的其他分子，包括胰岛素，胰岛素样生长因子结合蛋白（IGFBP）和IGFBP蛋白酶，都具有在慢性炎症性气道疾病中的作用。这篇综述旨在提供对IGF1 /胰岛素网络在慢性炎症性气道疾病中作用的最新研究的全面见解。它参与了气道炎症，重塑和高反应性（AHR）以及急性加重，已得到最终证明。还表明了它与糖皮质激素不敏感性的可能关系。通过进一步的台式研究，可以更好地了解IGF1 /胰岛素网络，可以为我们提供针对慢性炎症性气道疾病的合理临床治疗方法。

关键词: IGF1，胰岛素，IGFBP，慢性炎症性气道疾病，COPD，哮喘。

« Previous Next »

[1] 
Boulet, L.P.; Reddel, H.K.; Bateman, E.; Pedersen, S.; FitzGerald, J.M.; O’Byrne, P.M. The Global Initiative for Asthma (GINA): 25 years later. Eur. Respir. J.,  2019, 54(2)1900598
[http://dx.doi.org/10.1183/13993003.00598-2019] [PMID: 31273040] 
[2] 
Halpin, D.M.G.; Celli, B.R.; Criner, G.J.; Frith, P.; López Varela, M.V.; Salvi, S.; Vogelmeier, C.F.; Chen, R.; Mortimer, K.; Montes de Oca, M.; Aisanov, Z.; Obaseki, D.; Decker, R.; Agusti, A. It is time for the world to take COPD seriously: a statement from the GOLD board of directors. Eur. Respir. J.,  2019, 54(1)1900914
[http://dx.doi.org/10.1183/13993003.00914-2019] [PMID: 31273036] 
[3] 
Wang, Z.; Li, W.; Guo, Q.; Wang, Y.; Ma, L.; Zhang, X. Insulin-like growth factor-1 signaling in lung development and inflammatory lung diseases. BioMed Res. Int.,  2018, 20186057589
[http://dx.doi.org/10.1155/2018/6057589] [PMID: 30018981] 
[4] 
Yamanaka, Y.; Wilson, E.M.; Rosenfeld, R.G.; Oh, Y. Inhibition of insulin receptor activation by insulin-like growth factor binding proteins. J. Biol. Chem.,  1997, 272(49), 30729-30734.
[http://dx.doi.org/10.1074/jbc.272.49.30729] [PMID: 9388210] 
[5] 
Mazerbourg, S.; Monget, P. Insulin-like growth factor binding proteins and IGFBP proteases: a dynamic system regulating the ovarian folliculogenesis. Front. Endocrinol. (Lausanne),  2018, 9, 134.
[http://dx.doi.org/10.3389/fendo.2018.00134] [PMID: 29643837] 
[6] 
Wetterau, L.A.; Moore, M.G.; Lee, K.W.; Shim, M.L.; Cohen, P. Novel aspects of the insulin-like growth factor binding proteins. Mol. Genet. Metab.,  1999, 68(2), 161-181.
[http://dx.doi.org/10.1006/mgme.1999.2920] [PMID: 10527667] 
[7] 
Noveral, J.P.; Bhala, A.; Hintz, R.L.; Grunstein, M.M.; Cohen, P. Insulin-like growth factor axis in airway smooth muscle cells. Am. J. Physiol.,  1994, 267(6 Pt 1), L761-L765.
[http://dx.doi.org/10.1152/ajplung.1994.267.6.L761] [PMID: 7528983] 
[8] 
Chand, H.S.; Harris, J.F.; Mebratu, Y.; Chen, Y.; Wright, P.S.; Randell, S.H.; Tesfaigzi, Y. Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cells. J. Immunol.,  2012, 188(9), 4581-4589.
[http://dx.doi.org/10.4049/jimmunol.1102673] [PMID: 22461702] 
[9] 
Chetty, A.; Cao, G.J.; Nielsen, H.C. Insulin-like growth factor-I signaling mechanisms, type I collagen and alpha smooth muscle actin in human fetal lung fibroblasts. Pediatr. Res.,  2006, 60(4), 389-394.
[http://dx.doi.org/10.1203/01.pdr.0000238257.15502.f4] [PMID: 16940243] 
[10] 
Singh, S.; Bodas, M.; Bhatraju, N.K.; Pattnaik, B.; Gheware, A.; Parameswaran, P.K.; Thompson, M.; Freeman, M.; Mabalirajan, U.; Gosens, R.; Ghosh, B.; Pabelick, C.; Linneberg, A.; Prakash, Y.S.; Agrawal, A. Hyperinsulinemia adversely affects lung structure and function. Am. J. Physiol. Lung Cell. Mol. Physiol.,  2016, 310(9), L837-L845.
[http://dx.doi.org/10.1152/ajplung.00091.2015] [PMID: 26919895] 
[11] 
Rajah, R.; Nachajon, R.V.; Collins, M.H.; Hakonarson, H.; Grunstein, M.M.; Cohen, P. Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle. Am. J. Respir. Cell Mol. Biol.,  1999, 20(2), 199-208.
[http://dx.doi.org/10.1165/ajrcmb.20.2.3148] [PMID: 9922210] 
[12] 
Rajah, R.; Nunn, S.E.; Herrick, D.J.; Grunstein, M.M.; Cohen, P. Leukotriene D4 induces MMP-1, which functions as an IGFBP pro-tease in human airway smooth muscle cells. Am. J. Physiol.,  1996, 271(6 Pt 1), L1014-L1022.
[http://dx.doi.org/10.1152/ajplung.1996.271.6.L1014] [PMID: 8997273] 
[13] 
Meyer, K.F.; Krauss-Etschmann, S.; Kooistra, W.; Reinders-Luinge, M.; Timens, W.; Kobzik, L.; Plösch, T.; Hylkema, M.N. Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring. Am. J. Physiol. Lung Cell. Mol. Physiol.,  2017, 312(4), L542-L555.
[http://dx.doi.org/10.1152/ajplung.00271.2016] [PMID: 28130259] 
[14] 
Veraldi, K.L.; Gibson, B.T.; Yasuoka, H.; Myerburg, M.M.; Kelly, E.A.; Balzar, S.; Jarjour, N.N.; Pilewski, J.M.; Wenzel, S.E.; Feghali-Bostwick, C.A. Role of insulin-like growth factor binding protein-3 in allergic airway remodeling. Am. J. Respir. Crit. Care Med.,  2009, 180(7), 611-617.
[http://dx.doi.org/10.1164/rccm.200810-1555OC] [PMID: 19608721] 
[15] 
He, J.; Mu, M.; Wang, H.; Ma, H.; Tang, X.; Fang, Q.; Guo, S.; Song, C. Upregulated IGF 1 in the lungs of asthmatic mice originates from alveolar macrophages. Mol. Med. Rep.,  2019, 19(2), 1266-1271.
[http://dx.doi.org/10.3892/mmr.2018.9726] [PMID: 30535455] 
[16] 
Ye, M.; Yu, H.; Yu, W.; Zhang, G.; Xiao, L.; Zheng, X.; Wu, J. Evaluation of the significance of circulating insulin-like growth factor-1 and C-reactive protein in patients with chronic obstructive pulmonary disease. J. Int. Med. Res.,  2012, 40(3), 1025-1035.
[http://dx.doi.org/10.1177/147323001204000321] [PMID: 22906275] 
[17] 
Ruan, W.; Yan, C.; Zhu, H.; Wang, S.; Jia, X.; Shao, L.; Xu, Z.; Ying, K. Downregulated level of insulin in COPD patients during AE; role beyond glucose control? Int. J. Chron. Obstruct. Pulmon. Dis.,  2019, 14, 1559-1566.
[http://dx.doi.org/10.2147/COPD.S197164] [PMID: 31409982] 
[18] 
Machado, F.V.C.; Pitta, F.; Hernandes, N.A.; Bertolini, G.L. Physiopathological relationship between chronic obstructive pulmonary disease and insulin resistance. Endocrine,  2018, 61(1), 17-22.
[http://dx.doi.org/10.1007/s12020-018-1554-z] [PMID: 29512058] 
[19] 
Esnault, S.; Kelly, E.A.; Schwantes, E.A.; Liu, L.Y.; DeLain, L.P.; Hauer, J.A.; Bochkov, Y.A.; Denlinger, L.C.; Malter, J.S.; Mathur, S.K.; Jarjour, N.N. Identification of genes expressed by human airway eosinophils after an in vivo allergen challenge. PLoS One,  2013, 8(7)e67560
[http://dx.doi.org/10.1371/journal.pone.0067560] [PMID: 23844029] 
[20] 
Acat, M.; Toru Erbay, U.; Sahin, S.; Arik, O.; Ayada, C. High serum levels of IGF-I and IGFBP3 may increase comorbidity risk for asthmatic patients. Bratisl. Lek Listy,  2017, 118(11), 691-694.
[http://dx.doi.org/10.4149/BLL_2017_130] [PMID: 29216726] 
[21] 
Lee, Y.C.; Jogie-Brahim, S.; Lee, D.Y.; Han, J.; Harada, A.; Murphy, L.J.; Oh, Y. Insulin-like growth factor-binding protein-3 (IGFBP-3) blocks the effects of asthma by negatively regulating NF-κB signaling through IGFBP-3R-mediated activation of caspases. J. Biol. Chem.,  2011, 286(20), 17898-17909.
[http://dx.doi.org/10.1074/jbc.M111.231035] [PMID: 21383009] 
[22] 
Ruan, W.; Wu, M.; Shi, L.; Li, F.; Dong, L.; Qiu, Y.; Wu, X.; Ying, K. Serum levels of IGFBP7 are elevated during acute exacerbation in COPD patients. Int. J. Chron. Obstruct. Pulmon. Dis.,  2017, 12, 1775-1780.
[http://dx.doi.org/10.2147/COPD.S132652] [PMID: 28684903] 
[23] 
(a)Drake, K.A.; Torgerson, D.G.; Gignoux, C.R.; Galanter, J.M.; Roth, L.A.; Huntsman, S.; Eng, C.; Oh, S.S.; Yee, S.W. A genome-wide association study of bronchodilator
response in Latinos implicates rare variants. J. Allergy Clin. Immunol.,  2014, 133(2), 370-378.
[http://dx.doi.org/10.1016/j.jaci.2013.06.043] [PMID: 23992748] 
(b)Yan, X.; Baxter, R.C.; Firth, S.M. Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteoly-sis during pregnancy: a potential mechanism for increasing IGF bioavailability. J. Clin. Endocrinol. Metab.,  2010, 95(3), 1412-1420.
[http://dx.doi.org/10.1210/jc.2009-2277] [PMID: 20103653] 
[24] 
Talay, F.; Tosun, M.; Yaşar, Z.A.; Kar Kurt, Ö.; Karği, A.; Öztürk, S.; Özlü, M.F.; Alçelik, A. Evaluation of pregnancy-associated plasma protein-A levels in patients with chronic obstructive pulmonary disease and associations with disease severity. Inflammation,  2016, 39(3), 1130-1133.
[http://dx.doi.org/10.1007/s10753-016-0345-z] [PMID: 27090654] 
[25] 
Corbo, G.M.; Di Marco Berardino, A.; Mancini, A.; Inchingolo, R.; Smargiassi, A.; Raimondo, S.; Valente, S. Serum level of testos-terone, dihydrotestosterone and IGF-1 during an acute exacerbation of COPD and their relationships with inflammatory and prognostic indices: a pilot study. Minerva Med.,  2014, 105(4), 289-294.
[PMID: 24844347] 
[26] 
Piñeiro-Hermida, S.; López, I.P.; Alfaro-Arnedo, E.; Torrens, R.; Iñiguez, M.; Alvarez-Erviti, L.; Ruíz-Martínez, C.; Pichel, J.G. IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model. Sci. Rep.,  2017, 7(1), 4290.
[http://dx.doi.org/10.1038/s41598-017-04561-4] [PMID: 28655914] 
[27] 
López, I.P.; Piñeiro-Hermida, S.; Pais, R.S.; Torrens, R.; Hoeflich, A.; Pichel, J.G. Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during repair kinetics after selective club cell ablation. PLoS One,  2016, 11(11)e0166388
[http://dx.doi.org/10.1371/journal.pone.0166388] [PMID: 27861515] 
[28] 
Piñeiro-Hermida, S.; Gregory, J.A.; López, I.P.; Torrens, R.; Ruíz-Martínez, C.; Adner, M.; Pichel, J.G. Attenuated airway hyperre-sponsiveness and mucus secretion in HDM-exposed Igf1r-deficient mice. Allergy,  2017, 72(9), 1317-1326.
[http://dx.doi.org/10.1111/all.13142] [PMID: 28207927] 
[29] 
(a)Shao, Y.; Chong, L.; Lin, P.; Li, H.; Zhu, L.; Wu, Q.; Li, C. MicroRNA-133a alleviates airway remodeling in
asthtama through PI3K/AKT/mTOR signaling pathway by
targeting IGF1R. J. Cell. Physiol.,  2019, 234(4), 4068-4080.
[http://dx.doi.org/10.1002/jcp.27201] [PMID: 30146725] 
(b)Piñeiro-Hermida, S.; Alfaro-Arnedo, E.; Gregory, J.A.; Torrens, R.; Ruíz-Martínez, C.; Adner, M.; López, I.P. Characterization of the acute inflammatory profile and resolu-tion of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma. PLoS One,  2017, 12(12)e0190159
[http://dx.doi.org/10.1371/journal.pone.0190159] [PMID: 29272313] 
(c)Liu, D.; Pan, J.; Zhao, D.; Liu, F. MicroRNA-223 inhibits deposition of the extracellular matrix by airway smooth muscle cells through targeting IGF-1R in the PI3K/Akt pathway. Am. J. Transl. Res.,  2018, 10(3), 744-752.
[PMID: 29636864] 
[30] 
Ferreira, S.S.; Nunes, F.P.B.; Casagrande, F.B.; Martins, J.O. Insulin modulates cytokine release, collagen and mucus secretion in lung remodeling of allergic diabetic mice. Front. Immunol.,  2017, 8, 633.
[http://dx.doi.org/10.3389/fimmu.2017.00633] [PMID: 28649241] 
[31] 
Kim, S.R.; Lee, K.S.; Lee, K.B.; Lee, Y.C. Recombinant IGFBP-3 inhibits allergic lung inflammation, VEGF production, and vascular leak in a mouse model of asthma. Allergy,  2012, 67(7), 869-877.
[http://dx.doi.org/10.1111/j.1398-9995.2012.02837.x] [PMID: 22563687] 
[32] 
Vijayan, A.; Guha, D.; Ameer, F.; Kaziri, I.; Mooney, C.C.; Bennett, L.; Sureshbabu, A.; Tonner, E.; Beattie, J.; Allan, G.J.; Edwards, J.; Flint, D.J. IGFBP-5 enhances epithelial cell adhesion and protects epithelial cells from TGFβ1-induced mesenchymal invasion. Int. J. Biochem. Cell Biol.,  2013, 45(12), 2774-2785.
[http://dx.doi.org/10.1016/j.biocel.2013.10.001] [PMID: 24120850] 
[33] 
Yin, H.; Zhang, S.; Sun, Y.; Li, S.; Ning, Y.; Dong, Y.; Shang, Y.; Bai, C. MicroRNA-34/449 targets IGFBP-3 and attenuates airway remodeling by suppressing Nur77-mediated autophagy. Cell Death Dis.,  2017, 8(8)e2998
[http://dx.doi.org/10.1038/cddis.2017.357] [PMID: 28796252] 
[34] 
Coskun, A.; Balbay, O.; Duran, S.; Annakkaya, A.N.; Bulut, I.; Yavuz, O.; Kurt, E. Pregnancy-associated plasma protein-A and asthma. Adv. Ther.,  2007, 24(2), 362-367.
[http://dx.doi.org/10.1007/BF02849905] [PMID: 17565927] 
[35] 
Frystyk, J.; Schou, A.J.; Heuck, C.; Vorum, H.; Lyngholm, M.; Flyvbjerg, A.; Wolthers, O.D. Prednisolone reduces the ability of serum to activate the IGF1 receptor in vitro without affecting circulating total or free IGF1. Eur. J. Endocrinol.,  2012, 168(1), 1-8.
[http://dx.doi.org/10.1530/EJE-12-0518] [PMID: 23038624] 
[36] 
Escoll, P.; Ranz, I.; Muñoz-Antón, N.; van-den-Rym, A.; Alvarez-Mon, M.; Martínez-Alonso, C.; Sanz, E.; de-la-Hera, A. Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids. Mediators Inflamm.,  2015, 2015347965
[http://dx.doi.org/10.1155/2015/347965] [PMID: 25977599] 
[37] 
Bui, H.; Amrani, Y.; Deeney, B.; Panettieri, R.A.; Tliba, O. Airway smooth muscle cells are insensitive to the anti-proliferative effects of corticosteroids: the novel role of insulin growth factor binding Protein-1 in asthma. Immunobiology,  2019, 224(4), 490-496.
[http://dx.doi.org/10.1016/j.imbio.2019.05.006] [PMID: 31133345] 
[38] 
Castaldi, P.J.; Benet, M.; Petersen, H.; Rafaels, N.; Finigan, J.; Paoletti, M.; Marike Boezen, H.; Vonk, J.M.; Bowler, R.; Pistolesi, M.; Puhan, M.A.; Anto, J.; Wauters, E.; Lambrechts, D.; Janssens, W.; Bigazzi, F.; Camiciottoli, G.; Cho, M.H.; Hersh, C.P.; Barnes, K.; Rennard, S.; Boorgula, M.P.; Dy, J.; Hansel, N.N.; Crapo, J.D.; Tesfaigzi, Y.; Agusti, A.; Silverman, E.K.; Garcia-Aymerich, J. Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts. Thorax,  2017, 72(11), 998-1006.
[http://dx.doi.org/10.1136/thoraxjnl-2016-209846] [PMID: 28637835] 
[39] 
Yousuf, A.; Brightling, C.E. Biologic drugs: a new target therapy in COPD? COPD,  2018, 15(2), 99-107.
[http://dx.doi.org/10.1080/15412555.2018.1437897] [PMID: 29683730] 
[40] 
Stein, C.A.; Castanotto, D. FDA-approved oligonucleotide therapies in 2017. Mol. Ther.,  2017, 25(5), 1069-1075.
[http://dx.doi.org/10.1016/j.ymthe.2017.03.023] [PMID: 28366767] 
[41] 
Ti, H.; Zhou, Y.; Liang, X.; Li, R.; Ding, K.; Zhao, X. Targeted treatments for chronic obstructive pulmonary disease (COPD) using low-molecular-weight drugs (LMWDs). J. Med. Chem.,  2019, 62(13), 5944-5978.
[http://dx.doi.org/10.1021/acs.jmedchem.8b01520] [PMID: 30682248] 

Rights & Permissions Print Cite

Article Metrics

29

Journal Information

For Authors

For Editors

For Reviewers

Explore Articles

Open Access

Open Access Articles

For Visitors

DOI https://dx.doi.org/10.2174/0929867326666191113140826	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X

当代药物化学

慢性炎症性气道疾病中胰岛素样生长因子1 /胰岛素网络的新方面。

摘要

当代药物化学

慢性炎症性气道疾病中胰岛素样生长因子1 /胰岛素网络的新方面。

摘要 Play Pause

Related Journals

Related Books

Related Articles

摘要