Recent Developments on Ketolides and Macrolides

Yong-Jin      Wu; Wei-Guo      Su

doi:10.2174/0929867013371671

Abstract

Recent semi-synthetic studies of erythromycin A culminated in the discovery of two ketolide drug candidates, HMR-3647 and ABT-773, for the treatment of community-acquired bacterial infections caused by both macrolide- and β-lactam-susceptible and -resistant S. pneumoniae, gram negative bacteria, and intracellular atypical pathogens. The discovery of ketolides has rekindled interest in macrolides, and recent efforts have also led to a novel class of 4”-carbamates with activity against macrolide-resistant organisms. This review is an account of recent developments on ketolides and macrolides in terms of both chemistry and antibacterial activity.

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Current Medicinal Chemistry

Title: Recent Developments on Ketolides and Macrolides

Volume: 8 Issue: 14

Author(s): Yong-Jin Wu and Wei-Guo Su

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Abstract: Recent semi-synthetic studies of erythromycin A culminated in the discovery of two ketolide drug candidates, HMR-3647 and ABT-773, for the treatment of community-acquired bacterial infections caused by both macrolide- and β-lactam-susceptible and -resistant S. pneumoniae, gram negative bacteria, and intracellular atypical pathogens. The discovery of ketolides has rekindled interest in macrolides, and recent efforts have also led to a novel class of 4”-carbamates with activity against macrolide-resistant organisms. This review is an account of recent developments on ketolides and macrolides in terms of both chemistry and antibacterial activity.

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Wu Yong-Jin and Su Wei-Guo, Recent Developments on Ketolides and Macrolides, Current Medicinal Chemistry 2001; 8 (14) . https://dx.doi.org/10.2174/0929867013371671