Mechanism-Based Inhibition of Zinc Proteases

Dong   H.   Kim; Shahriar      Mobashery

doi:10.2174/0929867013372805

Abstract

The functions of zinc proteases have been implicated in a host of physiological and pathological processes in living organisms. Mechanism-based inhibitors are highly sought as biologically active molecules that afford high selectivity in targeting specific enzymes. Mechanism-based inhibitors for zinc-dependent proteases have been developed in the past several years. These inhibitors exploit the chemistry inherent to transition metals in their mechanisms of enzyme inhibition. These efforts have been reviewed in this manuscript.

Keywords: Inhibition of Zinc Proteases, carboxypeptidase A CPA, Epoxide-containing Inhibitors

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Current Medicinal Chemistry

Title: Mechanism-Based Inhibition of Zinc Proteases

Volume: 8 Issue: 8

Author(s): Dong H. Kim and Shahriar Mobashery

Affiliation:

Keywords: Inhibition of Zinc Proteases, carboxypeptidase A CPA, Epoxide-containing Inhibitors

Abstract: The functions of zinc proteases have been implicated in a host of physiological and pathological processes in living organisms. Mechanism-based inhibitors are highly sought as biologically active molecules that afford high selectivity in targeting specific enzymes. Mechanism-based inhibitors for zinc-dependent proteases have been developed in the past several years. These inhibitors exploit the chemistry inherent to transition metals in their mechanisms of enzyme inhibition. These efforts have been reviewed in this manuscript.

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Kim H. Dong and Mobashery Shahriar, Mechanism-Based Inhibition of Zinc Proteases, Current Medicinal Chemistry 2001; 8 (8) . https://dx.doi.org/10.2174/0929867013372805