On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries.

Title: On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries.

Volume: 4 Issue: 3

Author(s): Liang Tang, William. L. Fitch, Peter Smith, David Tumelty, Kathy Cao and Steven W. Ferla

Affiliation:

Keywords: High Throughput Reversed, Combinatorial Chemistry Libraries, liquid chromatography, Reversed Phase HPLC Columns, dioctyl phthalate, CTC syringe, TentaGel

Abstract: An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.

Cite this article as:

Tang Liang, Fitch L. William., Smith Peter, Tumelty David, Cao Kathy and Ferla W. Steven, On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries., Combinatorial Chemistry & High Throughput Screening 2001; 4 (3) . https://dx.doi.org/10.2174/1386207013331110