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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

星形胶质细胞：从生理到疾病

卷 16, 期 8, 2019

页: [675 - 698] 页: 24

弟呕挨: 10.2174/1567205016666190830110152

价格: $65

摘要

星形胶质细胞是关键的细胞，用于足够的大脑形成和调节脑血流量，以及维持神经元代谢，神经递质合成和胞吐作用以及突触传递。 这些功能中的许多与神经退行性变有内在相关，从而使人们可以重新关注星形胶质细胞在生理和神经退行性状态中的作用。 实际上，该领域的新证据表明，星形胶质细胞功能异常与多种神经退行性疾病的发病机制有关，包括阿尔茨海默氏病（AD），帕金森氏病（PD），亨廷顿氏病（HD）和肌萎缩性侧索硬化症（ALS）。 在当前的审查中，我们强调星形胶质细胞在中枢神经系统的生理作用，包括它们与大脑中其他细胞的通讯。 此外，我们讨论了令人兴奋的发现和新颖的实验方法，阐明了星形胶质细胞在多种神经系统疾病中的作用。

关键词: 星形胶质细胞，神经退行性疾病，阿尔茨海默病，帕金森病，亨廷顿病，肌萎缩侧索硬化症，神经炎症。

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