Antiviral Activities of Human Host Defense Peptides

doi:10.2174/0929867326666190805151654
摘要

具有广谱抗菌活性的肽被发现在整个自然界中广泛表达。由于它们参与哺乳动物先天免疫的许多不同方面，因此被称为宿主防御肽（HDD）。由于它们的共同结构特征，包括两亲性结构和阳离子电荷，它们已被广泛证明与微生物膜相互作用并破坏微生物膜。因此，人类HDP具有针对包膜病毒以及细菌和真菌的活性也就不足为奇了。然而，这些肽还表现出针对多种非包膜病毒的活性，在病毒感染的许多不同步骤中起作用。这篇综述着重于人类宿主防御肽，包括α-防御素和β-防御素以及唯一的人类cathelicidin LL-37对包膜和非包膜病毒的活性。这些肽在体外和体内的广泛抗病毒活性表明，它们在先天抗病毒防御病毒感染中起着重要作用。此外，文献表明它们可以被开发成抗病毒治疗剂。
关键词: 抗菌肽，宿主防御肽，病毒，防御素，LL-37，天然免疫..
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DOI https://dx.doi.org/10.2174/0929867326666190805151654	Print ISSN 0929-8673
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