This textbook provides a comprehensive overview of the part of dentistry that links basic physiologic and pathophysiologic mechanisms to frequently encountered problems in dental practice. Themes that are covered include the structure and function of the cells of oral mucosa, the biology of bone, the functions of oral mucosa, some important aspects on oral microbial flora and biofilms and finally the current principles on mastication, swallowing and speech. The knowledge of basic sciences is essential in oral biology, helping to understand the nature and behavior of cells, tissues and organs in health and disease. It is an easy-to-read, relatively brief but a comprehensive Ebook appropriate for undergraduate and graduate dental students as well as for practicing clinicians.

The biophysics of diving and decompression in the human body are complex. The average individual experiences atmospheric pressure swings of 3% at sea level and over 20% at altitudes greater than a mile. Divers and their equipment can experience compressions and decompressions in orders of greater magnitude than pressures outside water, all within considerably shorter time spans. The understanding of the mechanics behind diving is based on absolute pressure and pressure changes. While these mechanics are readily quantified in physics, chemistry, and engineering applications, the physiological and medical aspects of pressure changes in living systems need to be understood clearly to assess the safety of routine divers. This monograph is a compilation of a body of knowledge on biophysics, gas transport, bubble studies and physiological models used for diving and hyperbaric applications. Information in the monograph is divided into three parts that cover biophysics and models, data correlation and validation approaches and practical applications, respectively. The book is a useful resource for researchers and maritime professionals who wish to understand the biophysics behind underwater diving and decompression for the purpose of maritime operations as well as diving simulation applications.

Age-related degeneration may be reduced or even eliminated, by positively challenging the human being, physically or cognitively, to up-regulate somatic repair functions. Exposure to meaningful information and a challenging environment act as hormetic stressors which, in the context of an increasingly technological setting, may invoke evolutionary mechanisms that lead to a persistent maintenance of homeostasis. Thus, there is a strong link between environmental factors and ongoing health, leading to an individual’s ability to continually adapt to age related challenges. Challenging Ageing: The Anti-senescence Effects of Hormesis, Environmental Enrichment, and Information Exposure explains the role of hormesis in anti-aging processes followed by information on vitagenes, epigenetics, environmental enrichment and germlines. The monograph also brings newer concepts and theories to the fore, such as ‘environmental enrichment’ and ‘technoculture.’ Medical professionals and general readers, alike, will gain a a new perspective on the processes that counter aging processes in the human being.

Comparative bioacoustics is extraordinarily broad in scope. It includes the study of sound propagation, dispersion, attenuation, absorption, reverberation, and signal degradation as well as sound detection, recognition, and classification in both marine and terrestrial organisms (including humans). This research is informed by an understanding of the mechanisms underlying sound generation and aural reception, as well as the anatomy and physiology of the organs dedicated to these functions. Comparative Bioacoustics is the definitive introductory guide to the field of acoustics in animal and human biology. Key features of this volume are: -Comprehensive introduction to sound and related physical phenomena -Multidisciplinary and comparative analyses of bioacoustic phenomena -Integrated audio and video clips -Information about relevant research methods in bioacoustics Comparative Bioacoustics makes key information accessible to readers, therefore, meeting the requirements of both novice and advanced researchers preparing for a scholarly career in bioacoustics.

Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.

Some arrangements and structures of permanent magnets are hypothesized to exert measurable physiological and pathological effects on living tissues when exposed to the resultant electromagnetic field. From Microbe to Man: Biological responses to artificial static magnetic field-exposure explores the effects of such arrangements based on this hypothesis. The book begins with an explanation of the mechanisms of artificial static magnetic fields (SMFs). This is followed by sequential sections presenting the effects of SMF exposure on living organisms backed by thorough experimental studies (on microbial, animal and human trials). In conclusion, the work reveals the positive nature of SMF treatment and shows that this is indeed a viable alternative to invasive treatment in the case of a number of both acute and chronic conditions, such as stomatological pain and osteoporosis. From Microbe to Man: Biological responses to artificial static magnetic field-exposure is aimed chiefly at medical professionals and the research community studying alternatives to conventional pain medicine and physiotherapy. However, laypeople interested in non-invasive medical treatment options can also benefit from the easy-to-read layout of the contents of this volume.

Melanin is a biological molecule associated with pigmentation in humans and animals. However, melanin has been observed to have other functions such as neuroprotection and energy production. In Melanin, the Master Molecule, researchers summarize several decades worth of knowledge on melanin and its physicochemical properties. Nine chapters explain the intrinsic biochemistry of melanin, comparisons with conventional energy producing and respiratory biomolecules, the property of melanin to transform light energy into chemical energy through the dissociation of the water molecule, and the theories of melanin based energy production in the nervous system, the cell nucleus, muscles and the eye, and the role the role of melanin in the context of ageing. The authors also delve into the possibility of melanin being the key molecule needed to spark life since its water dissociating property through the absorption of light energy emulates the role of chlorophyll, but unlike the latter, it is not limited to the plant cell environment. Hence, melanin is referred to as the master molecule which can provide a missing link to the biochemical processes behind the origin of life. Melanin, the Master Molecule is an exciting reference for biochemists and laymen interested in the science of melanin and a new perspective on the origin of life as we know it.

Events of reproduction occurring from meiotic resumption of the immature oocyte up to its exit from the second meiotic block following activation will be revealed. Morphological modifications of the oocyte during maturation will be related to signal transduction mechanisms involving primary or secondary messengers. A detailed view will be addressed to genetic and epigenetic control of oocyte maturation. At fertilization, reciprocal gamete activation and novel knowledge related to sperm factor and cascade mechanisms occurring in the oocyte will be focused. A detailed description of ion currents occurring during fertilization will depict another point of view of oocyte activation mechanisms, further supporting for their complexity. Finally, all basic information related to this short time lapse will be considered in relation to clinical application of assisted reproductive technologies. New frontiers, such as stem cells and cloning technologies, will be analyzed and future applications and improvements will be hypothesised.

When environmental conditions deviate from the optimal range, stress ensues. Stress response is a set of reactions that allow the organism to adjust and survive adverse conditions. Stress can be physical, such as extreme temperature, radiation, injury, or psychological, caused by perceived danger or deprivation. Every living cell has biochemical mechanisms to cope with physical stress. These mechanisms show a degree of similarity among several types of living organisms. <p></p> Stress Response and Immunity: Links and Trade Offs explores the functional and evolutionary connections between stress response and immunity. The book introduces the reader to the concept of stress and subsequently examines the connection between stress response and immunity at various evolutionary stages of living organisms - from bacteria to humans. The book also features chapters dedicated to the role of tumor suppressor genes and the immune system of the brain. <p></p> The information presented in this reference demonstrates the profound effects of physical and psychological stress on human health. Readers with basic knowledge of molecular biology will learn about the interesting facets of stress responses and the evolutionary trade offs observed in different life forms.

This atlas covers basic as well as novel information on the retinae of various representative vertebrates including fish, amphibians, reptiles, birds, and mammals. The book consists of over 200 illustrations with brief descriptions pointing out special features of each retina displayed. The detailed information on the complexity and variety of visual cells in different animals will give interested readers an insight on the retinae of vertebrates. The book is divided into the following sections 1) the general architecture of retinae in different groups of animals 2) the types of visual cells in different vertebrates 3) the other retinal cells and synapses 4) the degenerating retina 5) general format of vertebrate retinal development. This atlas provides a sufficient framework in comparative retinal studies to inspire new research in the field of functional ophthalmology and biodiversity of visual cells. The book should be a useful reference for biologists, veterinarians, ophthalmologists, and eye researchers.