Recent Advances in Alzheimer Research

Common Pathogenic Mechanisms between Down Syndrome and Alzheimer`s Disease Steps toward Therapy

Volume: 1

Editor(s) : Ahmad Salehi, Michael Rafii, Cristy Phillips

DOI: 10.2174/97816810813801150101
eISBN: 978-1-68108-138-0, 2015
ISBN: 978-1-68108-139-7
ISSN: 2452-2554 (Print)
ISSN: 2452-2562 (Online)

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Request history8.2.27PHP Version240msRequest Duration27MBMemory UsageGET ebook_volume/{id}/{page_name?}/{param?}Route
    • Booting (145ms)time
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    • 1 x Booting (60.47%)
      145ms
      1 x Application (39.53%)
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      10 templates were rendered
      • ebook.ebook_volume_relatedebook_volume_related.blade.php#?blade
      • layouts.ebook_volume_header_sectionebook_volume_header_section.blade.php#?blade
      • ...related_ebooksrelated_ebooks.blade.php#?blade
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      uri
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      • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
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        • 9. middleware::check_user_access:24
        • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
        • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
      • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('59354538','',1,1740471875,1740471875) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740471875
        980μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
        Backtrace
        • 11. middleware::check_user_access:24
        • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
        • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
      • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('59354538','/ebook_volume/1875/related-ebooks?page=12',1,1740471875,1740471875)
        190μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
        Backtrace
        • 11. middleware::check_user_access:27
        • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
        • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
      • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59354538 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59354538) limit 1
        12.21msalphaeurekaselec_live_10_06_2022UserAccess.php#784
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        • 1: 59354538
        • 2: 59354538
        • 3: 59354538
        • 4: 59354538
        • 5: 59354538
        • 6: 59354538
        • 7: 59354538
        • 8: 59354538
        • 9: 59354538
        • 10: 59354538
        • 11: 59354538
        • 12: 59354538
        • 13: 59354538
        • 14: 59354538
        • 15: 59354538
        Backtrace
        • 14. app/Models/UserAccess/UserAccess.php:784
        • 15. middleware::check_user_access:114
        • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
        • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • select `year`, `id` from `year` order by `year` asc
        220μsalphaeurekaselec_live_10_06_2022Journal.php#197
        Backtrace
        • 13. app/Models/Journal.php:197
        • 14. app/Http/Controllers/EbookVolumeController.php:1555
        • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = '1875' and `e`.`is_uploaded` = 1
        1.23msalphaeurekaselec_live_10_06_2022EbookVolume.php#271
        Bindings
        • 0: 1875
        • 1: 1
        Backtrace
        • 13. app/Models/EbookVolume.php:271
        • 14. app/Http/Controllers/EbookVolumeController.php:1556
        • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select `ie`.`index_id`, `ie`.`ebook_volume_id`, `i`.`title` from `indexing_ebook` as `ie` left join `indexing_agencies` as `i` on `ie`.`index_id` = `i`.`index_id` where `ie`.`ebook_volume_id` = '1875' and `i`.`status` = 1 order by `i`.`title` asc
        810μsalphaeurekaselec_live_10_06_2022Indexing.php#345
        Bindings
        • 0: 1875
        • 1: 1
        Backtrace
        • 13. app/Models/Indexing.php:345
        • 14. app/Http/Controllers/EbookVolumeController.php:1557
        • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select count(*) as aggregate from (select `chapter`.*, group_concat(a.first_name,' ',a.last_name) as author_name from `chapter` left join `author` as `a` on `a`.`chapter_id` = `chapter`.`chapter_id` where `chapter`.`ebook_volume_id` = '1875' and `chapter`.`is_uploaded` = 1 group by `chapter`.`chapter_id`) as `aggregate_table`
        1.36msalphaeurekaselec_live_10_06_2022Chapter.php#97
        Bindings
        • 0: 1875
        • 1: 1
        Backtrace
        • 16. app/Models/Chapter.php:97
        • 17. app/Http/Controllers/EbookVolumeController.php:1568
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select `chapter`.*, group_concat(a.first_name,' ',a.last_name) as author_name from `chapter` left join `author` as `a` on `a`.`chapter_id` = `chapter`.`chapter_id` where `chapter`.`ebook_volume_id` = '1875' and `chapter`.`is_uploaded` = 1 group by `chapter`.`chapter_id` order by `chapter`.`chapter_no` asc limit 100 offset 1100
        820μsalphaeurekaselec_live_10_06_2022Chapter.php#97
        Bindings
        • 0: 1875
        • 1: 1
        Backtrace
        • 14. app/Models/Chapter.php:97
        • 15. app/Http/Controllers/EbookVolumeController.php:1568
        • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select * from `ebook` where `ebook_id` = 496 limit 1
        290μsalphaeurekaselec_live_10_06_2022EbookVolumeController.php#1570
        Bindings
        • 0: 496
        Backtrace
        • 16. app/Http/Controllers/EbookVolumeController.php:1570
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
      • select count(*) rcd from `ebook_volume` where `ebook_id` = 496 and ebook_volume_id <> 1875 limit 1
        360μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
        Bindings
        • 0: 496
        Backtrace
        • 14. app/Models/EbookVolume.php:999
        • 15. app/Http/Controllers/EbookVolumeController.php:1571
        • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=496) and se.ebook_id!=496 and v.ebook_status='1'
        2.53msalphaeurekaselec_live_10_06_2022Subject.php#238
        Backtrace
        • 16. app/Models/Subject.php:238
        • 17. app/Http/Controllers/EbookVolumeController.php:1574
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=496) and se.ebook_id!=496 and v.ebook_status='1' limit 10 offset 110
        2.65msalphaeurekaselec_live_10_06_2022Subject.php#238
        Backtrace
        • 14. app/Models/Subject.php:238
        • 15. app/Http/Controllers/EbookVolumeController.php:1574
        • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=496)
        410μsalphaeurekaselec_live_10_06_2022Subject.php#255
        Backtrace
        • 16. app/Models/Subject.php:255
        • 17. app/Http/Controllers/EbookVolumeController.php:1575
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=496) limit 10 offset 110
        540μsalphaeurekaselec_live_10_06_2022Subject.php#255
        Backtrace
        • 14. app/Models/Subject.php:255
        • 15. app/Http/Controllers/EbookVolumeController.php:1575
        • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`ebook_volume_id` = '1875' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
        1.17msalphaeurekaselec_live_10_06_2022Author.php#86
        Bindings
        • 0: 1875
        Backtrace
        • 13. app/Models/Author.php:86
        • 14. app/Http/Controllers/EbookVolumeController.php:1919
        • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1875 and `b`.`banner_from_date` <= 1740471875 and `b`.`banner_to_date` >= 1740471875 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
        1.1msalphaeurekaselec_live_10_06_2022Banner.php#95
        Bindings
        • 0: 1
        • 1: B
        • 2: 1875
        • 3: 1740471875
        • 4: 1740471875
        • 5: A
        Backtrace
        • 13. app/Models/Banner.php:95
        • 14. app/Http/helpers.php:404
        • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
      • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1875 and `b`.`banner_from_date` <= 1740471875 and `b`.`banner_to_date` >= 1740471875 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
        1.07msalphaeurekaselec_live_10_06_2022Banner.php#95
        Bindings
        • 0: 1
        • 1: B
        • 2: 1875
        • 3: 1740471875
        • 4: 1740471875
        • 5: A
        Backtrace
        • 13. app/Models/Banner.php:95
        • 14. app/Http/helpers.php:404
        • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
      • select count(*) as aggregate from `uc_cart_products` where cart_id='0c3fafb5560741d49a8275e17bf498ed'
        230μsalphaeurekaselec_live_10_06_2022Cart.php#271
        Backtrace
        • 15. app/Models/Cart.php:271
        • 16. view::layouts._header:260
        • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
      App\Models\Ebook
      1Ebook.php#?
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          ClearShow all
          Date ↕MethodURLData
          #12025-02-25 08:24:35GET/ebook_volume/1875/related-ebooks?page=1210181