Oxygen is historically entwined from its discovery with radical applications as a panacea by charlatans and by daring men constructing bridges using underwater caissons. Oxygen has made possible the exploration of the depths of the oceans beginning with hard-hat diving suits and extending to scuba gear, underwater habitats and submarines as well as space exploration. Molecular oxygen is critically involved in health and disease in more ways than any other element. It is essential for metabolism of food to nourish our bodies. Understanding its biological and chemical nature helps us to understand the effects of exercise, vitamins and supplements, and drugs used for cancer therapies. Oxygen, the Breath of Life is a comprehensive reference on the historical, biological, chemical and medical aspects of oxygen. Readers, both laymen and experts, will gain knowledge of the basics of oxygen chemistry, how it functions in the human body, the role of oxidants in the development of various diseases. Chapters contain historical notes which highlight the discoveries of pioneering researchers.

<i>Protocols used in Molecular Biology</i> is a compilation of several examples of molecular biology protocols. Each example is presented with a concise introduction, materials and chemicals required, a step-by-step procedure and troubleshooting tips. Information about the application of the protocol is also provided. The techniques included in this book are essential to research in the fields of proteomics, genomics, cell culture, epigenetic modification and structural biology. The protocols can also be used by clinical researchers (neuroscientists and oncologists, for example) for medical applications (diagnostics, therapeutics and multidisciplinary projects).

This monograph focuses on the actions exerted by sex hormones, 17β-estradiol and testosterone, in skeletal muscle tissue. An important consideration of this volume is the fact that both estrogen receptors (ERs) and androgen receptors (ARs) are ubiquitously expressed and, as a result, steroid hormones affect growth and different cell functions in several organs. Moreover, ERs and ARs may have a non-classical pattern of intracellular localizations, raising complexity to the functional roles of estradiol and testosterone. </p><p> Readers will find key information about the role of sex hormones in mitochondrial physiology and their relation with ageing, apoptosis, and sarcopenia. Chapters integrate important points with the latest information on the subject, including work of leading researchers studying the cellular and molecular mechanisms underlying the age-linked changes in muscle tissue while highlighting the role of satellite cells. </p><p> Furthermore, the book presents a chapter about phytoestrogens (compounds which are structurally very similar to estrogen 17β-estradiol) and their selective action on sex steroid receptors (specifically, they have a higher affinity for ERβ receptors than ERα receptors). </p><p> The book is recommended reading for scientists and clinicians involved in the field of medical and health sciences as well as for scholarly readers (students of biochemistry and medicine) who are interested in the molecular mechanism of cellular apoptosis regulated by steroid hormones.

The interactions between carbohydrates and proteins have been extensively explored in a wide range of physiological and pathological processes over several decades. The recent emergence of glycomics has strengthened this interest and notably contributed to spectacular progress in understanding how carbohydrates mediate and regulate complex biological events. Synthesis and Biological Applications of Glycoconjugates gives a summary of contemporary findings in glycoconjugate research. Readers will be updated on major achievements in chemical methods and biological applications employed in modern glycomics. The Ebook should be of interest to a broad community of students and professional researchers in both academia and industry.

Poisons, due to their lethal nature, invoke a sense of fear in humans. Yet, they have also impacted other aspects of human life. Poisons have been used by nomadic hunters to kill their prey, by scientists to explore complex biochemical mechanisms of the body, by physicians to lower cholesterol and to kill cancer cells, by farmers and the general public to destroy pests, by the evil minded for homicide, and by tyrants as weapons of war. The Art and Science of Poisons presents two facets of poisons: the science behind them and their place in history and art. The science of poisons describes their biochemistry and how they kill. The science story voyages into the sub-microscopic world of atoms, molecules, and cells. Only there can we see the true miracles and mysteries of life and death. Chapters in the book explore poisons from snakes, spiders, scorpions, sea creatures, as well as poisons made by humans in the laboratory, and those which are derived from beautiful plants. The art of poisons, on the other hand, encompasses everything else about these agents that conjures up the image of the skull and crossbones. This side of the story explores the legends and tales of intrigue and surreptitious deaths of well-known personalities such as Socrates, Cleopatra, Hitler, and many more. General readers with a curiosity about science and an interest in history and human nature will enjoy both facets presented in this brief, yet varied exploration into the world of poisons.

This reference explores the science of signaling mechanisms associated with diseases like endocrine, metabolic, and immune disorders which are linked to oxidative stress-mediated disease mechanisms. The common diseases in these categories include diabetes mellitus and arthritis and conditions defined by inflammation and autoimmunity. These diseases involve metabolic pathways mediated by reactive oxygen species or free radicals. The pathways are targets in the mechanism of drugs that aim to treat related disorders. The book covers key topics in free radical biology that help to understand the nature of the pathways and the pharmacology of the drugs that are designed to target them. 5 chapters elucidate the free radical biology of the diseases. 1. Role of free radical biology in diabetes mellitus 2. Role of GSK3 in the regulation of insulin release and glucose metabolism 3. Regulatory role of NRF2 in rheumatoid arthritis 4. Role of free radical biology in Alzheimer's disease 5. Regulatory role of immune cells mediated antibody on rheumatoid arthritis Key features: - Elucidates the key biochemical and pharmacological mechanisms that are mediated by free radicals in common endocrine, metabolic and immune diseases - Explains the activation of immunological factors (like RF and ACPA) that trigger inflammation and arthritis - Covers the role of free radicals in Alzheimer's disease and new interventions that target mitochondrial mechanisms - Systematically explains the molecular biology of free radicals with the help of schematic diagrams - Includes references for further reading The accessible and structured text in this reference makes it a suitable resource for all biomedical scientists, faculty, and postgraduate students in academia and industry.

Bio-based polymers are materials that are produced from renewable resources. Their biodegradable properties are the driver of worldwide interest among researchers and manufacturers in recent years due to the demand and need for alternatives to fossil fuel based polymers. The use of biodegradable polymers creates a sustainable industry. In contrast, the raw materials for synthetic polymers derived from petrochemicals will eventually deplete and most of them are non-biodegradable. Despite these advantages, bio-based polymers account for only a tiny fraction of the total global plastic market. Non-biodegradability issues of synthetic pharmaceutical inactive ingredients strongly emphasized innovators towards the development of biopolymers. Recently natural biodegradable excipients gained significant attention due to their sustainability and engineered applications. Innovative technologies to transform these materials into value-added chemicals via novel graft-polymerization or co-processing techniques for the production of high-performance multifunctional and low-cost polymers with tunable structures are key parts of its sustainable development. Biopolymers Towards Green and Sustainable Development elaborates on important issues that surround bio-based polymers. It gives the reader an overview of biopolymers, the impact of non-biodegradable polymers on the environment and health, emerging sources of biodegradable polymers, structural and morphological characterization techniques, thermomechanical properties, biodegradable plastics from biopolymers, pharmaceutical, biomedical, and textile applications, and pharmacokinetics and pharmacodynamics. with a brief on bibliometric. Moreover, a brief bibliometric meta-analysis on bio-based pharmaceutical excipients provides an update about teams involved in the development of polymeric research that may be of interest to anyone who wants to work on sustainable biopolymer projects. Key Features - provides an updated summary on recently discovered natural polymeric materials - gives a thorough breakdown of the vast range of biopolymer applications including fabrication of conventional and novel drug delivery, polymeric scaffolds, composites, microneedles, and green synthesis of metallic nanoparticles, -summarizes pharmacology and pharmacokinetics of the inactive pharmaceutical ingredient and excipients - presents a bibliometric meta-analysis indicating potential collaboration between country, organization, institution, and authors with a view on recent ongoing trends with biopolymers.

Organotins are widespread contaminants especially of water environments. Their chemically versatile structure makes organotin compounds able to bind to a variety of biomolecules thus widely affecting biological functions. Trisubstituted molecules, namely tributyltin (TBT) and triphenyltin (TPhT), have been widely employed in antifouling paints and are also exploited as plastic stabilizers that unfortunately cause harmful biological effects. Persistent bioaccumulation has resulted in organotins becoming a significant environmental threat. Chapter by chapter, the biological and biochemical effects of organotins are unravelled in this e-book by a careful analysis of the most recent findings with special focus on contaminant action mechanisms at cellular and molecular level. The e-book provides an intriguing insight into the molecular mechanisms involved in organotin toxicology thus serving as a useful reference to biochemists, biologists, ecotoxicologists and life science students.