Iatrogenic Pathology of the Skin and Subcutaneous Tissue

Abstract

The skin and liver are the most common organs affected by the side effects of drugs. Drug-related damage to the skin and subcutaneous tissue is presented in detail in this chapter. Benign lesions include contact dermatitis and eczematous eruptions. Severe drug-induced injuries include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), acute generalized exanthematous pustulosis, bullous dermatoses and other hypersensitivity syndromes. The specific characteristics and responsible agents of these conditions are offered in tables in this chapter, and particular types of drug-induced lesions are also presented. A significant part of the chapter focuses on the effects of targeted cancer therapies on the skin and subcutaneous tissue. Granulomas and vaccine-induced lesions are also examined.

Keywords: Adverse drug reaction, Allergy, Antibody, Contact dermatitis, Dermatosis, DRESS syndrome, Eczema, eruption, Hyperpigmentation, Hypersensitivity, Iatrogenic, Pustulosis, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Vitiligo.