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Review Article

关于营养作为慢性疼痛止痛剂的见解

卷 27, 期 37, 2020

页: [6407 - 6423] 页: 17

弟呕挨: 10.2174/0929867326666190712172015

价格: $65

摘要

许多严重的炎症紊乱和营养缺乏会导致慢性疼痛，抗炎饮食已成功应用于改善引起慢性疼痛的炎症症状。大量科学数据和临床研究表明，长期炎症可导致对疼痛的不适当或夸大的敏感性。此外，一些非甾体抗炎药(NSAID)可直接作用于许多与疼痛和炎症有关的酶，包括环氧合酶，可抑制痛觉信号传递给中枢神经系统，减少软c纤维对疼痛刺激的反应。另一方面，卫生当局和医生都有一些报告称，疼痛信号的传递可以减少并得到改善，这取决于患者的饮食习惯。许多营养物质以及适当水平的运动(抗阻训练)是提高肌肉细胞线粒体总容量的最佳方法，这可以降低对疼痛的敏感性，特别是通过降低向c纤维发出的炎症信号。根据目前的文献，慢性疼痛可能是由于神经肽、激素的比例变化和营养不良造成的，通常与潜在的炎症障碍有关。本综述还评估了营养相关干预对慢性疼痛严重程度的有效作用。本文综述指出，营养干预可通过间接抑制前列腺素E2，减弱骨骼肌缺血/再灌注引起的线粒体功能障碍，改善细胞内抗氧化防御系统，从而对疼痛体验产生积极影响。这些数据突出表明，需要进行更多的营养研究，以慢性疼痛为主要结果，采用准确的干预措施。到目前为止，还没有针对慢性疼痛的营养建议被正式提出。因此，本文的目标是探讨疼痛管理和疼痛调节，寻找一种有效的营养模式减轻疼痛。

关键词: 疼痛，膳食，营养补充，锻炼，COX-2

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